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Journal: F1000Research

Abbreviation

Publisher

F1000Research

Journal Volumes

ISSN

2046-1402

Description

Filters

2015 - 20205
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Publications 1 - 5 of 5
  • Disinhibition, an emerging pharmacology of learning and memory
    Item type: Review Article
    Möhler, Hanns; Rudolph, Uwe (2017)
    F1000Research
    Learning and memory are dependent on interactive excitatory and inhibitory mechanisms. In this review, we discuss a mechanism called disinhibition, which is the release of an inhibitory constraint that effectively results in an increased activity in the target neurons (for example, principal or projection neurons). We focus on discussing the role of disinhibition in learning and memory at a basic level and in disease models with cognitive deficits and highlight a strategy to reverse cognitive deficits caused by excess inhibition, through disinhibition of α5-containing GABAA receptors mediating tonic inhibition in the hippocampus, based on subtype-selective negative allosteric modulators as a novel class of drugs.
  • Virtual-screening workflow tutorials and prospective results from the Teach-Discover-Treat competition 2014 against malaria
    Item type: Other Publication
    Riniker, Sereina; Landrum, Gregory A.; Montanari, Floriane; et al. (2017)
    F1000Research
  • A dynamic architecture of life
    Item type: Review Article
    Rubin, Beatrix P.; Brockes, Jeremy; Galliot, Brigitte; et al. (2015)
    F1000Research
  • Reproducibly sampling SARS-CoV-2 genomes across time, geography, and viral diversity
    Item type: Journal Article
    Bolyen, Evan; Dillon, Matthew R.; Bokulich, Nicholas; et al. (2020)
    F1000Research
    The COVID-19 pandemic has led to a rapid accumulation of SARS-CoV-2 genomes, enabling genomic epidemiology on local and global scales. Collections of genomes from resources such as GISAID must be subsampled to enable computationally feasible phylogenetic and other analyses. We present genome-sampler, a software package that supports sampling collections of viral genomes across multiple axes including time of genome isolation, location of genome isolation, and viral diversity. The software is modular in design so that these or future sampling approaches can be applied independently and combined (or replaced with a random sampling approach) to facilitate custom workflows and benchmarking. genome-sampler is written as a QIIME 2 plugin, ensuring that its application is fully reproducible through QIIME 2’s unique retrospective data provenance tracking system. genome-sampler can be installed in a conda environment on macOS or Linux systems. A complete default pipeline is available through a Snakemake workflow, so subsampling can be achieved using a single command. genome-sampler is open source, free for all to use, and available at https://caporasolab.us/genome-sampler. We hope that this will facilitate SARS-CoV-2 research and support evaluation of viral genome sampling approaches for genomic epidemiology.
  • On the pitfalls of peer review
    Item type: Journal Article
    van Gunsteren, Wilfred F. (2015)
    F1000Research
    The review process of academic, scientific research and its basic tenets is considered, thereby distinguishing between (i) reviewing of manuscripts to be published in the scientific literature, (ii) reviewing of research proposals to be financed by funding agencies, (iii) reviewing of educational or research institutions with respect to their proper functioning, and (iv) reviewing of scientists with the aim of appointing or tenuring faculty.
Publications 1 - 5 of 5