Anticipatory countering of motor challenges by premovement activation of orexin neurons
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Date
2022-11
Publication Type
Journal Article
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yes
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Abstract
Countering upcoming challenges with anticipatory movements is a fundamental function of the brain, whose neural implementations remain poorly defined. Recently, premovement neural activation was found outside canonical premotor areas, in the hypothalamic hypocretin/orexin neurons (HONs). The purpose of this hypothalamic activation is unknown. By studying precisely defined mouse–robot interactions, here we show that the premovement HON activity correlates with experience-dependent emergence of anticipatory movements that counter imminent motor challenges. Through targeted, bidirectional optogenetic interference, we demonstrate that the premovement HON activation governs the anticipatory movements. These findings advance our understanding of the behavioral and cognitive impact of temporally defined HON signals and may provide important insights into healthy adaptive movements.
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published
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Volume
1 (5)
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Publisher
Oxford University Press
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Subject
motor control; skilled movements; hypothalamus; predictive control
Organisational unit
03827 - Gassert, Roger / Gassert, Roger
09589 - Burdakov, Denis / Burdakov, Denis