Circulation: Cardiovascular Imaging

Journal: Circulation: Cardiovascular Imaging

Publisher

Lippincott Williams & Wilkins

ISSN

1941-9651
1942-0080

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Publications 1 - 9 of 9

Studying Dynamic Myofiber Aggregate Reorientation in Dilated Cardiomyopathy Using in Vivo Magnetic Resonance Diffusion Tensor Imaging
Deuster, von Deuster, Constantin; Sammut, Eva; Asner, Liya; et al. (2016)
Circulation: Cardiovascular Imaging
Background The objective of this study is to assess the dynamic alterations of myocardial microstructure and strain between diastole and systole in patients with dilated cardiomyopathy relative to healthy controls using the magnetic resonance diffusion tensor imaging, myocardial tagging, and biomechanical modeling. Methods and Results Dual heart-phase diffusion tensor imaging was successfully performed in 9 patients and 9 controls. Tagging data were acquired for the diffusion tensor strain correction and cardiac motion analysis. Mean diffusivity, fractional anisotropy, and myocyte aggregate orientations were compared between both cohorts. Cardiac function was assessed by left ventricular ejection fraction, torsion, and strain. Computational modeling was used to study the impact of cardiac shape on fiber reorientation and how fiber orientations affect strain. In patients with dilated cardiomyopathy, a more longitudinal orientation of diastolic myofiber aggregates was measured compared with controls. Although a significant steepening of helix angles (HAs) during contraction was found in the controls, consistent change in HAs during contraction was absent in patients. Left ventricular ejection fraction, cardiac torsion, and strain were significantly lower in the patients compared with controls. Computational modeling revealed that the dilated heart results in reduced HA changes compared with a normal heart. Reduced torsion was found to be exacerbated by steeper HAs. Conclusions Diffusion tensor imaging revealed reduced reorientation of myofiber aggregates during cardiac contraction in patients with dilated cardiomyopathy relative to controls. Left ventricular remodeling seems to be an important factor in the changes to myocyte orientation. Steeper HAs are coupled with a worsening in strain and torsion. Overall, the findings provide new insights into the structural alterations in patients with dilated cardiomyopathy.
Advanced Cardiovascular Magnetic Resonance Myocardial Perfusion Imaging High-Spatial Resolution Versus 3-Dimensional Whole-Heart Coverage
Motwani, Manish; Jogiya, Roy; Kozerke, Sebastian; et al. (2013)
Circulation: Cardiovascular Imaging
Sustained Ventricular Tachyarrhythmias are Associated With Increased ¹⁸F-Fluorodeoxyglucose Uptake Mimicking Cardiac Sarcoidosis
Kovacs, Boldizsar; Giannopoulos, Andreas A.; Bogun, Frank; et al. (2024)
Circulation: Cardiovascular Imaging
Complex Congenital Heart Disease Associated With Disordered Myocardial Architecture in a Midtrimester Human Fetus
Garcia-Canadilla, Patricia; Dejea, Hector; Bonnin, Anne; et al. (2018)
Circulation: Cardiovascular Imaging
Multicenter Evaluation of Dynamic Three-Dimensional Magnetic Resonance Myocardial Perfusion Imaging for the Detection of Coronary Artery Disease Defined by Fractional Flow Reserve
Manka, Robert; Wissmann, Lukas; Gebker, Rolf; et al. (2015)
Circulation: Cardiovascular Imaging
Turbulent Kinetic Energy Assessed by Multipoint 4-Dimensional Flow Magnetic Resonance Imaging Provides Additional Information Relative to Echocardiography for the Determination of Aortic Stenosis Severity
Binter, Christian; Gotschy, Alexander; Sündermann, Simon H.; et al. (2017)
Circulation: Cardiovascular Imaging
Ischemic burden by 3-dimensional myocardial perfusion cardiovascular magnetic resonance: Comparison with myocardial perfusion scintigraphy
Jogiya, Roy; Morton, Geraint; De Silva, Kalpa; et al. (2014)
Circulation: Cardiovascular Imaging
Different Prognostic Value of Functional Right Ventricular Parameters in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Saguner, Ardan M.; Vecchiati, Alessandra; Baldinger, Samuel H.; et al. (2014)
Circulation: Cardiovascular Imaging
Influence of left ventricular hypertrophy and geometry on diagnostic accuracy of wall motion and perfusion magnetic resonance during dobutamine stress
Gebker, Rolf; Mirelis, Jesus G.; Jahnke, Cosima; et al. (2010)
Circulation: Cardiovascular Imaging

Publications 1 - 9 of 9

Journal: Circulation: Cardiovascular Imaging

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