Acoustophoretic cell and particle trapping on microfluidic sharp edges
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Date
2015-10
Publication Type
Journal Article
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yes
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Abstract
Cell and particle trapping experience a rising interest in a microfluidic context. Trapping of cells in suspension at distinct locations in a microfluidic domain is relevant for cell biological lab-on-a-chip systems, where a trap provides a well-definable microenvironment for cell response studies. This paper reports a novel acoustophoretic cell trapping effect on oscillating sharp edge structures which protrude into a microfluidic channel. These edge structures (125–250 μm length, 10–80 μm width in the experiments) were found to attract cells and particles strongly and reliably upon simple piezoelectric excitation around 1 MHz. The method is contact- and label-free, robust, and biocompatible. The physical trapping effect is experimentally characterized, and a numerical model is proposed, based on the theory of acoustic radiation forces.
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published
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Journal / series
Volume
19 (4)
Pages / Article No.
923 - 933
Publisher
Springer
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Edition / version
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Date collected
Date created
Subject
Acoustofluidics; Acoustophoresis; Acoustic radiation force; Acoustic streaming; Cell trapping
Organisational unit
03307 - Dual, Jürg (emeritus) / Dual, Jürg (emeritus)
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.