Stem-cell-associated structural and functional plasticity in the aging hippocampus
METADATA ONLY
Loading...
Author / Producer
Date
2008
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
METADATA ONLY
Data
Rights / License
Abstract
Aging frequently leads to a functional decline across multiple cognitive domains, often resulting in a severe reduction in life quality and also causing substantial care-related costs. Understanding age-associated structural and functional changes of neural circuitries within the brain is required to improve successful aging. In this review, the authors focus on age-dependent alterations of the hippocampus and the decline of hippocampal function, which are critically involved in processes underlying certain forms of learning and memory. Despite the dramatic reductions in hippocampus-dependent function that accompany advancing age, there is also striking evidence that even the aged brain retains a high level of plasticity. Thus, one promising avenue to reach the goal of successful aging might be to boost and recruit this plasticity, which is the interplay between neural structure, function, and experience, to prevent age-related cognitive decline and age-associated comorbidities.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
23 (4)
Pages / Article No.
684 - 691
Publisher
American Psychological Association
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Organisational unit
03776 - Jessberger, Sebastian (ehem.)
03367 - Suter, Ulrich (emeritus) / Suter, Ulrich (emeritus)