Towards artificial cells: electrofusion of lipid vesicles on-chip
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Author / Producer
Date
2018
Publication Type
Other Conference Item
ETH Bibliography
yes
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Abstract
We present a microelectrode platform, integrated on a microfluidic chip, to study electrofusion of giant lipid vesicles with smaller vesicles, such as large liposomes made of synthetic lipids and vesicles derived from HEK293T cells. We monitored the fusion through lipid mixing, specifically the transfer of labeled lipids onto the giant vesicle membrane. The method described here represents a key step towards the creation of hybrid vesicles and is ultimately valuable for the bottom-up creation of artificial cells.
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Publication status
published
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Editor
Book title
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2018)
Journal / series
Volume
Pages / Article No.
1390 - 1392
Publisher
Chemical and Biological Microsystems Society
Event
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2018)
Edition / version
Methods
Software
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Date collected
Date created
Subject
Artificial cells; Lipid vesicles; Cell-derived vesicles; Membrane fusion
Organisational unit
03807 - Dittrich, Petra / Dittrich, Petra
Notes
Poster abstract. Poster presentation on November 12, 2018.