Journal: Life sciences

Abbreviation

Life sci.

Publisher

Elsevier

Journal Volumes

ISSN

0024-3205
1879-0631

Description

Filters

2004 - 200932020 - 20231
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Publications 1 - 4 of 4
  • Isoform-specific downregulation of peroxiredoxin in human failing myocardium
    Item type: Journal Article
    Brixus, Klara; Schwinger, Robert H.G.; Hoyer, Felix; et al. (2007)
    Life sciences
  • Reduced glucocorticoid sensitivity of monocyte interleukin-6 release in male employees with high plasma levels of tumor necrosis factor-α
    Item type: Journal Article
    Wirtz, Petra H.; von Känel, Roland; Kunz-Ebrecht, Sabine; et al. (2004)
    Life sciences
  • The effect of repeated acute mental stress on habituation and recovery responses in hemoconcentration and blood cells in healthy men
    Item type: Journal Article
    Mischler, Katharina; Fischer, Joachim E.; Zgraggen, Lilian; et al. (2005)
    Life sciences
  • Aquaporin 4 is differentially increased and dislocated in association with tau and amyloid-beta
    Item type: Journal Article
    Kecheliev, Vasil; Boss, Leo; Maheshwari, Upasana; et al. (2023)
    Life sciences
    Aims: Neurovascular-glymphatic dysfunction plays an important role in Alzheimer's disease and has been analysed mainly in relation to amyloid-beta (Aβ) pathology. Here, we aim to investigate the neurovascular alterations and mapping of aquaporin 4 (AQP4) distribution and dislocation associated with tau and Aβ. Materials and methods: Perfusion, susceptibility weighted imaging and structural magnetic resonance imaging (MRI) were performed in the pR5 mouse model of 4-repeat tau and the arcAβ mouse model of amyloidosis. Immunofluorescence staining was performed using antibodies against AQP4, vessel, astroglia, microglia, phospho-tau and Aβ in brain tissue slices from pR5, arcAβ and non-transgenic mice. Key findings: pR5 mice showed regional atrophy, preserved cerebral blood flow, and reduced cerebral vessel density compared to non-transgenic mice, while arcAβ mice showed cerebral microbleeds and reduced cerebral vessel density. AQP4 dislocation and peri-tau enrichment in the hippocampus and increased AQP4 levels in the cortex and hippocampus were detected in pR5 mice compared to non-transgenic mice. In comparison, cortical AQP4 dislocation and cortical/hippocampal peri-plaque increases were observed in arcAβ mice. Increased expression of reactive astrocytes were detected around the tau inclusions in pR5 mice and Aβ plaques in arcAβ mice. Significance: We demonstrated the neurovascular alterations, microgliosis, astrogliosis and increased AQP4 regional expression in pR5 tau and arcAβ mice. We observed a divergent region-specific AQP4 dislocation and association with phospho-tau and Aβ pathologies.
Publications 1 - 4 of 4