Engineering T-cell Activation for Immunotherapy by Mechanical Forces
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Author / Producer
Date
2019-01
Publication Type
Journal Article
ETH Bibliography
yes
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Abstract
Adoptive immunotherapy relies on the isolation, modification, activation, and transfer of antigen-specific T-cells. With constant advances in bioengineering, each individual step in T-cell activation and expansion can be further improved. In this review, we discuss the current knowledge on factors influencing the mechanical forces applied on a T-cell during activation. We provide insights from ligand presentation and surface modification and present ideas of a mechanobiological signal transduction from extracellular receptor–ligand interaction to intranuclear gene expression changes as a determining factor of a T-cell response.
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Publication status
published
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Book title
Journal / series
Volume
10
Pages / Article No.
134 - 141
Publisher
Elsevier
Event
Edition / version
Methods
Software
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Date collected
Date created
Subject
Mechanobiology of T-cells; immunoengineering; T-cell activation; ligand spacing; force generation in T-cells
Organisational unit
08703 - Gruppe Klotzsch / Group Klotzsch