General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases
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Date
2024-09-10
Publication Type
Review Article
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yes
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Abstract
The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer. Finally, we summarize the barriers to effectively targeting GCN2 for the treatment of disease and to promote a healthier aging process.
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published
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Journal / series
Volume
5
Pages / Article No.
1447370
Publisher
Frontiers Media
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Subject
GCN2; ISR; amino acids; aging; gerotherapeutic; geroprotection; cancer