The gate to metastasis: key players in cancer cell intravasation
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Author / Producer
Date
2022-08
Publication Type
Review Article
ETH Bibliography
yes
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Abstract
Metastasis is a leading cause of cancer-related death and consists of a sequence of events including tumor expansion, intravasation of cancer cells into the circulation, survival in the bloodstream, extravasation at distant sites, and subsequent organ colonization. Particularly, intravasation is a process whereby cancer cells transverse the endothelium and leave the primary tumor site, pioneering the metastatic cascade. The identification of those mechanisms that trigger the entry of cancer cells into the bloodstream may reveal fundamentally novel ways to block metastasis at its start. Multiple factors have been implicated in cancer progression, yet, signals that unequivocally provoke the detachment of cancer cells from the primary tumor are still under investigation. Here, we discuss the role of intrinsic properties of cancer cells, tumor microenvironment, and mechanical cues in the intravasation process, outlining studies that suggest the involvement of various factors and highlighting current understanding and open questions in the field.
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Publication status
published
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Book title
Journal / series
Volume
289 (15)
Pages / Article No.
4336 - 4354
Publisher
Wiley
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
cancer; circulating tumor cells; intravasation; metastasis
Organisational unit
09736 - Aceto, Nicola / Aceto, Nicola
Notes
Funding
190077 - SNF-Förderungsprofessur PP00P3_190077 (SNF)
847012 - Understanding why the 'metastasisers' colonise and other circulating cancer cells do not (EC)
847012 - Understanding why the 'metastasisers' colonise and other circulating cancer cells do not (EC)