A Method for the Stereoselective Construction of the Hemiaminal Center in Zampanolides
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2020-11-06
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Journal Article
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Abstract
We have developed a new method for the stereoselective establishment of the N-acyl hemiaminal moiety in zampanolide-type structures that involves the reaction of (Z,E)-sorbamide (3) with BINAL-H and subsequent amide transfer from a putative aluminum carboximidoate complex to the aldehyde moiety of a dactylolide precursor, such as 2 or 5. The method has enabled the efficient synthesis of 13-desmethylene-(−)-zampanolide (4), which was found to be an equipotent cell growth inhibitor as the natural product (−)-zampanolide (1). © 2020 American Chemical Society
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22 (21)
Pages / Article No.
8345 - 8348
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American Chemical Society
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03647 - Altmann, Karl-Heinz (emeritus) / Altmann, Karl-Heinz (emeritus)