Joint Inference of Repeated Evolutionary Trajectories and Patterns of Clonal Exclusivity or Co-occurrence from Tumor Mutation Trees
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Date
2022
Publication Type
Conference Paper
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yes
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Abstract
Cancer progression is an evolutionary process shaped by both deterministic and stochastic forces. Recent advances in multi-region sequencing, single-cell sequencing, and phylogenetic tree inference empower more precise reconstruction of the mutational history of each tumor. At the same time, the increased resolution also highlights the extensive diversity across tumors and patients. Resolving the interactions among mutations and recovering the recurrent evolutionary processes may offer greater opportunities for designing successful therapeutic strategies.
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published
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Book title
Research in Computational Molecular Biology
Journal / series
Volume
13278
Pages / Article No.
304 - 305
Publisher
Springer
Event
26th Annual International Conference on Research in Computational Molecular Biology (RECOMB 2022)
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03790 - Beerenwinkel, Niko / Beerenwinkel, Niko