Ultrafast four-dimensional imaging of cardiac mechanical wave propagation with sparse optoacoustic sensing
METADATA ONLY
Loading...
Author / Producer
Date
2021-11-09
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
METADATA ONLY
Data
Rights / License
Abstract
Propagation of electromechanical waves in excitable heart muscles follows complex spatiotemporal patterns holding the key to understanding life-threatening arrhythmias and other cardiac conditions. Accurate volumetric mapping of cardiac wave propagation is currently hampered by fast heart motion, particularly in small model organisms. Here we demonstrate that ultrafast four-dimensional imaging of cardiac mechanical wave propagation in entire beating murine heart can be accomplished by sparse optoacoustic sensing with high contrast, ∼115-µm spatial and submillisecond temporal resolution. We extract accurate dispersion and phase velocity maps of the cardiac waves and reveal vortex-like patterns associated with mechanical phase singularities that occur during arrhythmic events induced via burst ventricular electric stimulation. The newly introduced cardiac mapping approach is a bold step toward deciphering the complex mechanisms underlying cardiac arrhythmias and enabling precise therapeutic interventions.
Permanent link
Publication status
published
External links
Editor
Book title
Volume
118 (45)
Pages / Article No.
Publisher
National Academy of Sciences
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
imaging ultrafast phenomena; optoacoustic tomography; photoacoustics; ultrafast volumetric imaging; Langendorff
Organisational unit
09648 - Razansky, Daniel / Razansky, Daniel