Tree-ensemble analysis assesses presence of multifurcations in single cell data
OPEN ACCESS
Loading...
Author / Producer
Date
2019-03-01
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
Data
Rights / License
Abstract
We introduce TreeTop, an algorithm for single cell data analysis to identify and assign a branching score to branch points in biological processes which may have multi‐level branching hierarchies. We demonstrate branch point identification for processes with varying topologies, including T‐cell maturation, B‐cell differentiation and hematopoiesis. Our analyses are consistent with recent experimental studies suggesting a shallower hierarchy of differentiation events in hematopoiesis, rather than the classical multi‐level hierarchy.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
15 (3)
Pages / Article No.
Publisher
Nature
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
computational biology; proteomics; single cell RNA-seq; trajectory inference
Organisational unit
03984 - Claassen, Manfred (ehemalig) / Claassen, Manfred (former)