Conserved stromal–immune cell circuits secure B cell homeostasis and function
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Date
2023-07
Publication Type
Journal Article, Journal Article
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no
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Abstract
B cell zone reticular cells (BRCs) form stable microenvironments that
direct efficient humoral immunity with B cell priming and memory
maintenance being orchestrated across lymphoid organs. However, a
comprehensive understanding of systemic humoral immunity is hampered
by the lack of knowledge of global BRC sustenance, function and major
pathways controlling BRC–immune cell interactions. Here we dissected
the BRC landscape and immune cell interactome in human and murine
lymphoid organs. In addition to the major BRC subsets underpinning the
follicle, including follicular dendritic cells, PI16+ RCs were present across
organs and species. As well as BRC-produced niche factors, immune
cell-driven BRC differentiation and activation programs governed the
convergence of shared BRC subsets, overwriting tissue-specific gene
signatures. Our data reveal that a canonical set of immune cell-provided
cues enforce bidirectional signaling programs that sustain functional BRC
niches across lymphoid organs and species, thereby securing efficient
humoral immunity.
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published
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Volume
24 (7)
Pages / Article No.
Publisher
Springer
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02520 - Institut für Mikrobiologie / Institute of Microbiology