Site-selective C(sp³)–H oxidation of alkyl substrates devoid of functional handles
OPEN ACCESS
Loading...
Author / Producer
Date
2025-03-13
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
OPEN ACCESS
Data
Rights / License
Abstract
Although the field of C(sp3)–H oxidation has progressed tremendously over the last decades, the selective oxidation of non-activated positions on hydrocarbon skeletons is still highly challenging. It usually requires the presence of a suitable functional handle in proximity to the desired oxidation site. Here, we present a novel approach to catalyst-directed C–H oxidation that relies on substrate binding via the solvophobic effect in fluorinated alcohols and thus is independent of specific functional groups on the substrate. The supramolecular catalyst Mn(mcp)-RS2 enables the preferential oxidation at the fifth position from the less-hindered side on aliphatic substrates.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
11 (3)
Pages / Article No.
102442
Publisher
Cell Press
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
C–H oxidation; alkanes; solvophobic effect; catalyst control; supramolecular catalyst