Pressure and Bernoulli-based Flow Measurement via a Tapered Inflow VAD Cannula
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Date
2022-05
Publication Type
Journal Article
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yes
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Abstract
Objective: Currently available ventricular assist
devices provide continuous flow and do not adapt to the changing
needs of patients. Physiological control algorithms have been
proposed that adapt the pump speed based on the left ventricular
pressure. However, so far, no clinically used pump can acquire this
pressure. Therefore, for the validation of physiological control
concepts in vivo, a system that can continuously and accurately
provide the left ventricular pressure signal is needed. Methods: We
demonstrate the integration of two pressure sensors into a tapered
inflow cannula compatible with the HeartMate 3 (HM3)
ventricular assist device. Selective laser melting was used to
incorporate functional elements with a small footprint and
therefore retain the geometry, function and implantability of the
original cannula. The system was tested on a hybrid mock
circulation system. Static and simulated physiological flow and
pressure profiles were used to evaluate the combined pressure and
flow sensing capabilities of the modified cannula. Results: The
cannula prototypes enabled continuous pressure measurements at
two points of their inner wall in the range of −100 and 200 mmHg.
The developed, Bernoulli-based, two sensor model improved the
accuracy of the measured simulated left ventricular pressure by
eliminating the influence of flow inside the cannula. This method
reduced the flow induced pressure uncertainty from up to
7.6 mmHg in single sensor measurements to 0.3 mmHg.
Additionally, the two-sensor system and model enable the
measurement of the blood flow through the pump with an
accuracy of −0.14±0.04 L/min, without dedicated flow sensors.
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published
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Journal / series
Volume
69 (5)
Pages / Article No.
1620 - 1629
Publisher
IEEE
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Date collected
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Subject
Bernoulli; blood flow sensor; blood pressure sensor; continuous monitoring; inflow cannula; paylene; physiological control; ventricular assist device
Organisational unit
03943 - Meboldt, Mirko / Meboldt, Mirko
03609 - Hierold, Christofer / Hierold, Christofer