Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan
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Date
2023-01-02
Publication Type
Review Article
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yes
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Abstract
Disrupted biological function, manifesting through the hallmarks of aging, poses one of the largest threats to healthspan and risk of disease development, such as metabolic disorders, cardiovascular ailments, and neurodegeneration. In recent years, numerous geroprotectors, senolytics, and other nutraceuticals have emerged as potential disruptors of aging and may be viable interventions in the immediate state of human longevity science. In this review, we focus on the decrease in nicotinamide adenine dinucleotide (NAD+) with age and the supplementation of NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), in combination with other geroprotective compounds, to restore NAD+ levels present in youth. Furthermore, these geroprotectors may enhance the efficacy of NMN supplementation while concurrently providing their own numerous health benefits. By analyzing the prevention of NAD+ degradation through the inhibition of CD38 or supporting protective downstream agents of SIRT1, we provide a potential framework of the CD38/NAD+/SIRT1 axis through which geroprotectors may enhance the efficacy of NAD+ precursor supplementation and reduce the risk of age-related diseases, thereby potentiating healthspan in humans.
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Publication status
published
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Book title
Journal / series
Volume
15 (2)
Pages / Article No.
445
Publisher
MDPI
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Edition / version
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Geographic location
Date collected
Date created
Subject
Aging; Longevity; Supplements; Geroprotectors; SIRT1; NAD+; NMN; Resveratrol; Nutraceuticals; Age-related diseases; Flavonoids; Senolytics; Healthspan
Organisational unit
09598 - Ewald, Collin Y. (ehemalig) / Ewald, Collin Y. (former)
Notes
Funding
190072 - Protein homeostasis of extracellular proteins during aging (SNF)