Proteomics. Clinical Applications

Journal: Proteomics. Clinical Applications

Abbreviation

Prot. Clin. Appl.

Publisher

Wiley-VCH

ISSN

1862-8346
1862-8354

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Publications 1 - 7 of 7

Surfaceome of classical Hodgkin and non-Hodgkin lymphoma
Hofmann, Andreas; Thiesler, Thore; Gerrits, Bertran; et al. (2015)
Proteomics. Clinical Applications
A Novel Role for Proteomics in the Discovery of Cell-Surface Markers on Stem Cells
Gundry, Rebekah L.; Boheler, Kenneth R.; Van Eyk, Jennifer E.; et al. (2008)
Proteomics. Clinical Applications
Using data-independent, high resolution mass spectrometry in protein biomarker Research: Perspectives and clinical applications
Sajic, Tatjana; Liu, Yansheng; Aebersold, Ruedi (2015)
Proteomics. Clinical Applications
Salivary Fingerprinting of Periodontal Disease by Infrared-ATR Spectroscopy
Beyer-Hans, Kerstin M.-C.; Sigrist, Markus W.; Silbereisen, Angelika; et al. (2020)
Proteomics. Clinical Applications
Label-Free Quantitative Proteomics versus Antibody-Based Assays to Measure Neutrophil-Derived Enzymes in Saliva
Silbereisen, Angelika; Alassiri, Saeed; Bao, Kai; et al. (2020)
Proteomics. Clinical Applications
Proteomics studies of pancreatic cancer
Chen, Ru; Pan, Sheng; Aebersold, Ruedi; et al. (2007)
Proteomics. Clinical Applications
Protein Network Alterations in G-CSF Treated Severe Congenital Neutropenia Patients and Beneficial Effects of Oral Health Intervention
Bao, Kai; Silbereisen, Angelika; Grossmann, Jonas; et al. (2024)
Proteomics. Clinical Applications
Purpose: Severe congenital neutropenia (SCN) is a raredisorder characterized by diminished neutrophil levels. Despite granulocytecolony-stimulating factor (G-CSF) treatment, SCN patients remain still prone tosevere infections, including periodontal disease—a significant oral healthrisk. This study investigates the host proteome and metaproteome in saliva andgingival crevicular fluid (GCF) of G-CSF-treated patients. Experimental Design: We used label-free quantitative proteomics on saliva and GCF samples from SCN patients before (n = 10, mean age: 10.7 ± 6.6 years) and after a 6-month oral hygiene intervention (n = 9,mean age: 11.6 ± 5.27 years), and from 12 healthy controls. Results: We quantified 894 proteins in saliva (648 human,246 bacterial) and 756 proteins in GCF (493 human, 263 bacterial). Predominant bacterial genera included Streptococcus, Veillonella, Selenomonas, Corynebacterium, Porphyromonas, and Prevotella. SCN patients showed reduced antimicrobial peptides (AMPs) and elevated complement proteins compared tohealthy controls. Oral hygiene intervention improved oral epithelial conditionsand reduced both AMPs and complement proteins. Conclusions and Clinical Relevance: SCN patients have aunique proteomic profile with reduced AMPs and increased complement proteins, contributing to infection susceptibility. Oral hygiene intervention not onlyimproved oral health in SCN patients but also offers potential overall therapeuticbenefits.

Publications 1 - 7 of 7

Journal: Proteomics. Clinical Applications

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