A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways
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Date
2020-03-03
Publication Type
Journal Article
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yes
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Abstract
Molenaars, Janssens, and colleagues report on a natural balance between cytosolic and mitochondrial ribosomal proteins, driven by an active link between two longevity pathways. They demonstrate that the inhibition of mitochondrial translation regulates cytosolic translation via the transcription factor Atf4/atf-5, a phenomenon conserved in worms, human cells, and in vivo in mice.
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published
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31 (3)
Pages / Article No.
549 - 563.e7
Publisher
Cell Press
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03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)
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670821 - Proteomics 4D: The proteome in context (EC)