Journal: Multiple Sclerosis Journal

Abbreviation

Mult Scler

Publisher

SAGE

Journal Volumes

ISSN

1352-4585
1477-0970

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Publications 1 - 6 of 6
  • Brain activation patterns elicited by the 'Faces Symbol Test'
    Item type: Journal Article
    Grabner, R.H.; Popotnig, F.; Ropele, S.; et al. (2008)
    Multiple Sclerosis Journal
  • How do patients enter the healthcare system after the first onset of multiple sclerosis symptoms? The influence of setting and physician specialty on speed of diagnosis
    Item type: Journal Article
    Barin, Laura; Kamm, Christian P.; Salmen, Anke; et al. (2020)
    Multiple Sclerosis Journal
    Background: Diagnosing multiple sclerosis (MS) early is crucial to avoid future disability. However, potentially preventable delays in the diagnostic cascade from contact with a physician to definite diagnosis still occur and their causes are still unclear. Objective: To identify the possible causes of delays in the diagnostic process. Methods: We analyzed the data of the Swiss MS Registry. With logistic regression, we modeled the time from the first contact to the first consultation (contact-to-evaluation time, ⩽1 month/>1 month) and the evaluation-to-diagnosis time (⩽6 months/>6 months). Potential factors were health system characteristics, sociodemographic variables, first symptoms, and MS type. Results: We included 522 participants. Mostly, general practitioners (67%) were contacted first, without delaying the diagnosis. In contrast, first symptoms and MS type were the major contributors to delays: gait problems were associated with longer contact-to-evaluation times, depression as a concomitant symptom with longer evaluation-to-diagnosis times, and having primary progressive MS prolonged both phases. In addition, living in mountainous areas was associated with longer contact-to-evaluation times, whereas diagnosis after 2000 was associated with faster diagnoses. Conclusion: For a quicker diagnosis, awareness of MS as a differential diagnosis of gait disorders and the co-occurrence of depression at onset should be raised, and these symptoms should be attentively followed.
  • Advanced lightweight cooling-garment technology
    Item type: Journal Article
    Meyer-Heim, A.; Rothmaier, M.; Weder, M.; et al. (2007)
    Multiple Sclerosis Journal
  • Continuous monitoring with wearables in multiple sclerosis reveals an association of cardiac autonomic dysfunction with disease severity
    Item type: Journal Article
    Hilty, Marc; Oldrati, Pietro; Barrios, Liliana; et al. (2022)
    Multiple Sclerosis Journal
    Background Dysfunction of the autonomic nervous system is common in multiple sclerosis patients, and probably present years before diagnosis, but its role in the disease is poorly understood. Objectives To study the autonomic nervous system in patients with multiple sclerosis using cardiac autonomic regulation measured with a wearable. Methods In a two-week study, we present a method to standardize the measurement of heart rate variability using a wearable sensor that allows the investigation of circadian trends. Using this method, we investigate the relationship of cardiac autonomic dysfunction with clinical hallmarks and subjective burden of fatigue and autonomic symptoms. Results In 55 patients with multiple sclerosis and 24 healthy age- and gender-matched controls, we assessed the cumulative circadian heart-rate variability trend of two weeks. The trend analysis revealed an effect of inflammation (P = 0.0490, SMD = -0.5466) and progressive neurodegeneration (P = 0.0016, SMD = 1.1491) on cardiac autonomic function. No association with subjective symptoms could be found. Conclusions Trend-based heart rate variability measured with a wearable provides the opportunity for unobtrusive long-term assessment of autonomic functions in patients with multiple sclerosis. It revealed a general dysregulation in patients with multiple sclerosis.
  • Monophasic course of disease in Lewis rats with focal experimental autoimmune encephalomyelitis (EAE)
    Item type: Other Conference Item
    Kapitza, S.; Zorner, B.; Bleul, C.; et al. (2013)
    Multiple Sclerosis Journal
  • High EDSS can predict risk for upper urinary tract damage in patients with multiple sclerosis
    Item type: Journal Article
    Ineichen, Benjamin V.; Schneider, Marc P.; Hlavica, Martin; et al. (2018)
    Multiple Sclerosis Journal
Publications 1 - 6 of 6