Journal: Arthritis Care & Research

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Wiley

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2019 - 201912020 - 20222
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Publications 1 - 3 of 3
  • Exercise Therapy for the Management of Femoroacetabular Impingement Syndrome: Preliminary Results of Clinical Responsiveness
    Item type: Journal Article
    Casartelli, Nicola C.; Bizzini, Mario; Maffiuletti, Nicola A.; et al. (2019)
    Arthritis Care & Research
  • Detection of Differences in Longitudinal Cartilage Thickness Loss Using a Deep-Learning Automated Segmentation Algorithm: Data From the Foundation for the National Institutes of Health Biomarkers Study of the Osteoarthritis Initiative
    Item type: Journal Article
    Eckstein, Felix; Chaudhari, Akshay S.; Fuerst, David; et al. (2022)
    Arthritis Care & Research
    Objective To study the longitudinal performance of fully automated cartilage segmentation in knees with radiographic osteoarthritis (OA), we evaluated the sensitivity to change in progressor knees from the Foundation for the National Institutes of Health OA Biomarkers Consortium between the automated and previously reported manual expert segmentation, and we determined whether differences in progression rates between predefined cohorts can be detected by the fully automated approach. Methods The OA Initiative Biomarker Consortium was a nested case-control study. Progressor knees had both medial tibiofemoral radiographic joint space width loss (>= 0.7 mm) and a persistent increase in Western Ontario and McMaster Universities Osteoarthritis Index pain scores (>= 9 on a 0-100 scale) after 2 years from baseline (n = 194), whereas non-progressor knees did not have either of both (n = 200). Deep-learning automated algorithms trained on radiographic OA knees or knees of a healthy reference cohort (HRC) were used to automatically segment medial femorotibial compartment (MFTC) and lateral femorotibial cartilage on baseline and 2-year follow-up magnetic resonance imaging. Findings were compared with previously published manual expert segmentation. Results The mean +/- SD MFTC cartilage loss in the progressor cohort was -181 +/- 245 mu m by manual segmentation (standardized response mean [SRM] -0.74), -144 +/- 200 mu m by the radiographic OA-based model (SRM -0.72), and -69 +/- 231 mu m by HRC-based model segmentation (SRM -0.30). Cohen's d for rates of progression between progressor versus the non-progressor cohort was -0.84 (P < 0.001) for manual, -0.68 (P < 0.001) for the automated radiographic OA model, and -0.14 (P = 0.18) for automated HRC model segmentation. Conclusion A fully automated deep-learning segmentation approach not only displays similar sensitivity to change of longitudinal cartilage thickness loss in knee OA as did manual expert segmentation but also effectively differentiates longitudinal rates of loss of cartilage thickness between cohorts with different progression profiles.
  • Effectiveness of Hip Arthroscopy on Treatment of Femoroacetabular Impingement Syndrome: A Meta-Analysis of Randomized Controlled Trials
    Item type: Journal Article
    Casartelli, Nicola C.; Valenzuela, Pedro L.; Maffiuletti, Nicola A.; et al. (2021)
    Arthritis Care & Research
    Objective To appraise the highest available evidence provided by randomized controlled trials (RCTs) on the effectiveness of hip arthroscopy versus physical therapy in patients with femoroacetabular impingement syndrome (FAIS). Methods Four databases (Medline, Embase, Web of Science, and Scopus) were systematically searched until October 1, 2019. Eligible studies were RCTs in which patients with FAIS underwent hip arthroscopy or physical therapy. The study outcome was the International Hip Outcome Tool, 33 Items (iHOT-33) score, a measure of hip pain, function, and quality of life, assessed at baseline and at the follow-up closer to 12 months after randomization. The pooled mean difference in iHOT-33 scores within and between the treatment arms was computed using a random effects model. The minimum clinically important difference in the iHOT-33 scores was set at 10 points. Results Three RCTs evaluating iHOT-33 scores between 6 and 8 months after the interventions were included. Significant increases in iHOT-33 scores were observed from baseline to follow-up for both hip arthroscopy (22.3 points [95% confidence interval (95% CI) 17.3–27.4]) and physical therapy (13.0 points [95% CI 9.5–16.4]). Hip arthroscopy demonstrated significantly higher iHOT-33 scores at follow-up compared with physical therapy (10.9 points [95% CI 4.7–17.0]). Conclusion Both hip arthroscopy and physical therapy resulted in statistically and clinically significant short-term improvements in hip pain, function, and quality of life in patients with FAIS. Hip arthroscopy was statistically superior to physical therapy in improving the outcome at follow-up even if improvement may not be detected by patients. (© 2020, American College of Rheumatology)
Publications 1 - 3 of 3