Dissecting the epigenetic regulation of human brain organoid development in single cells
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Date
2024-07
Publication Type
Journal Article
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yes
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Abstract
We present a developmental atlas that offers insight into sequential epigenetic changes underlying early human brain development modeled in organoids, which reconstructs the differentiation trajectories of all major CNS regions. It shows that epigenetic regulation via the installation of activating histone marks precedes activation of groups of neuronal genes.
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published
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Journal / series
Volume
27 (7)
Pages / Article No.
1219 - 1220
Publisher
Nature
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Subject
Cell fate and cell lineage; Data integration; Stem-cell differentiation; Systems biology
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