Classifying cancer-associated fibroblasts – The good, the bad, and the target
METADATA ONLY
Loading...
Author / Producer
Date
2024-09-09
Publication Type
Journal Article
ETH Bibliography
yes
Citations
Altmetric
METADATA ONLY
Data
Rights / License
Abstract
Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within the tumor microenvironment (TME). Numerous CAF types have been described, typically using single-cell technologies such as single-cell RNA sequencing. There is no general classification system for CAFs, hampering their study and therapeutic targeting. We propose a simple CAF classification system based on single-cell phenotypes and spatial locations of CAFs in multiple cancer types, assess how our scheme fits within current knowledge, and invite the CAF research community to further refine it.
Permanent link
Publication status
published
External links
Editor
Book title
Journal / series
Volume
42 (9)
Pages / Article No.
1480 - 1485
Publisher
Cell Press
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
Organisational unit
09735 - Bodenmiller, Bernd / Bodenmiller, Bernd