What are Sertoli cells? Historical, methodological, and functional aspects
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Author / Producer
Date
2023-07
Publication Type
Review Article
ETH Bibliography
yes
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Abstract
Sertoli cells are somatic cells that are in close contact with germ cells in the mammalian testes. They have multiple functions and fulfill key roles for the development and proper maturation of spermatogenic cells into functional spermatozoa. One of their most important properties is to release trophic factors and supply nutrients to germ cells. But they are also involved in the regulation of the immune system in testis, and provide an immunologically privileged environment for developing germ cells. Because they are so essential for reproductive cells, their alterations can have detrimental consequences for fertility. Many environmental factors and exposures such as high caloric diet, toxins, and pollutants are thought to compromise Sertoli cells physiology. This review describes the discovery of Sertoli cells and the methods used for their study, summarizes their major properties and functions, and describes their dysfunctions in pathologies, particularly associated with environmental stressors.
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Publication status
published
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Editor
Book title
Journal / series
Volume
11 (5)
Pages / Article No.
849 - 859
Publisher
Wiley-Blackwell
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
fertility; germ cells; methodological development; Sertoli cells
Organisational unit
03518 - Mansuy, Isabelle / Mansuy, Isabelle
00002 - ETH Zürich
Notes
Funding
182880 - NCCR RNA#38;Disease (51NF40-182880): Flexibility Grant (SNF)