Journal: Nature Nanotechnology

Abbreviation

Nat. Nanotechnol.

Publisher

Nature

Journal Volumes

ISSN

1748-3387
1748-3395

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Publications 1 - 10 of 95
  • Single-site iron-anchored amyloid hydrogels as catalytic platforms for alcohol detoxification
    Item type: Journal Article
    Su, Jiaqi; Wang, Pengjie; Zhou, Wei; et al. (2024)
    Nature Nanotechnology
    Constructing effective antidotes to reduce global health impacts induced by alcohol prevalence is a challenging topic. Despite the positive effects observed with intravenous applications of natural enzyme complexes, their insufficient activities and complicated usage often result in the accumulation of toxic acetaldehyde, which raises important clinical concerns, highlighting the pressing need for stable oral strategies. Here we present an effective solution for alcohol detoxification by employing a biomimetic-nanozyme amyloid hydrogel as an orally administered catalytic platform. We exploit amyloid fibrils derived from beta-lactoglobulin, a readily accessible milk protein that is rich in coordinable nitrogen atoms, as a nanocarrier to stabilize atomically dispersed iron (ferrous-dominated). By emulating the coordination structure of the horseradish peroxidase enzyme, the single-site iron nanozyme demonstrates the capability to selectively catalyse alcohol oxidation into acetic acid, as opposed to the more toxic acetaldehyde. Administering the gelatinous nanozyme to mice suffering from alcohol intoxication significantly reduced their blood-alcohol levels (decreased by 55.8% 300 min post-alcohol intake) without causing additional acetaldehyde build-up. Our hydrogel further demonstrates a protective effect on the liver, while simultaneously mitigating intestinal damage and dysbiosis associated with chronic alcohol consumption, introducing a promising strategy in effective alcohol detoxification.
  • Time-resolved imaging of three-dimensional nanoscale magnetization dynamics
    Item type: Journal Article
    Donnelly, Claire; Finizio, Simone; Gliga, Sebastian; et al. (2020)
    Nature Nanotechnology
  • Implementing clinical needs into the development of wearable health-monitoring technology
    Item type: Other Journal Item
    Brasier, Noé Karl; Domenghino, Anja; Meier, Christoph A.; et al. (2025)
    Nature Nanotechnology
    The implementation of clinical needs and feedback throughout the development cycle of wearable health-monitoring technology is key to success. Close collaboration with all stakeholders involved will speed clinical translation to the market.
  • Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks
    Item type: Journal Article
    Kasuba, Krishna Chaitanya; Buccino, Alessio Paolo; Bartram, Julian; et al. (2024)
    Nature Nanotechnology
    A growing consensus that the brain is a mechanosensitive organ is driving the need for tools that mechanically stimulate and simultaneously record the electrophysiological response of neurons within neuronal networks. Here we introduce a synchronized combination of atomic force microscopy, high-density microelectrode array and fluorescence microscopy to monitor neuronal networks and to mechanically characterize and stimulate individual neurons at piconewton force sensitivity and nanometre precision while monitoring their electrophysiological activity at subcellular spatial and millisecond temporal resolution. No correlation is found between mechanical stiffness and electrophysiological activity of neuronal compartments. Furthermore, spontaneously active neurons show exceptional functional resilience to static mechanical compression of their soma. However, application of fast transient (∼500 ms) mechanical stimuli to the neuronal soma can evoke action potentials, which depend on the anchoring of neuronal membrane and actin cytoskeleton. Neurons show higher responsivity, including bursts of action potentials, to slower transient mechanical stimuli (∼60 s). Moreover, transient and repetitive application of the same compression modulates the neuronal firing rate. Seemingly, neuronal networks can differentiate and respond to specific characteristics of mechanical stimulation. Ultimately, the developed multiparametric tool opens the door to explore manifold nanomechanobiological responses of neuronal systems and new ways of mechanical control.
  • Harnessing Biological Motors to Engineer Systems for Nanoscale Transport and Assembly
    Item type: Journal Article
    Goel, Anita; Vogel, Viola (2008)
    Nature Nanotechnology
  • Dynamic relaxation of a levitated nanoparticle from a non-equilibrium steady state
    Item type: Journal Article
    Gieseler, Jan; Quidant, Romain; Dellago, Christoph; et al. (2014)
    Nature Nanotechnology
  • Enzymatic reactions in confined environments
    Item type: Journal Article
    Küchler, Andreas; Yoshimoto, Makoto; Luginbühl, Sandra; et al. (2016)
    Nature Nanotechnology
  • Designing cryo-enzymatic reactions in subzero liquid water by lipidic mesophase nanoconfinement
    Item type: Journal Article
    Yao, Yang; Zhou, Tao; Farber, Raphael; et al. (2021)
    Nature Nanotechnology
    Cryo-enzymology provides the possibility to develop unconventional biological reactions and detect intermediates in ultrafast enzymatic catalysis processes, but also illuminates the understanding of life principles in extremely cold environments. The scarcity of biological or biomimetic host systems that provide liquid water at subzero temperatures inhibits the prosperity of cryo-enzymology. Here we introduce cryo-enzymatic reactions in subzero water nanoconfined within lipid mesophases formed by conventional lipids. We show that the enzymatic reactions that ensue outperform the homologue catalytic processes run at standard temperatures. We use phytantriol-based lipidic mesophases (LMPs), within which water remains in the liquid state down to −120 °C, and combine crystallization and dynamic studies of the confined water to provide a fundamental understanding of the physical status of water at subzero temperatures, which sets the stage for cryo-enzymatic reactions in these environments. In the model horseradish peroxidase oxidization, the cation free-radical product is stabilized in LMPs at −20 °C, in contrast to the fast-consuming reactions at temperatures above 0 °C. Furthermore, the LMP system also supports the cascade reaction and lipase reaction at subzero temperatures, at which enzymatic reactions with both hydrophilic and hydrophobic substrates are successfully carried out. Our designed LMP system opens access to the nature of confined water in the biomimetic environment and provides a platform for low-temperature biomacromolecule reconstitution and the cryogenic control of enzymatic reactions in bionanotechnology.
  • A tunable monolithic SQUID in twisted bilayer graphene
    Item type: Journal Article
    Portolés, Elías; Iwakiri, Shuichi; Zheng, Giulia; et al. (2022)
    Nature Nanotechnology
    Magic-angle twisted bilayer graphene (MATBG) hosts a number of correlated states of matter that can be tuned by electrostatic doping(1-4). Transport(5,6) and scanning-probe(7-9) experiments have shown evidence for band, correlated and Chern insulators along with superconductivity. This variety of in situ tunable states has allowed for the realization of tunable Josephson junctions(10-12). However, although phase-coherent phenomena have been measured(10-12), no control of the phase difference of the superconducting condensates has been demonstrated so far. Here we build on previous gate-defined junction realizations and form a superconducting quantum interference device(13) (SQUID) in MATBG, where the superconducting phase difference is controlled through the magnetic field. We observe magneto-oscillations of the critical current, demonstrating long-range coherence of superconducting charge carriers with an effective charge of 2e. We tune to both asymmetric and symmetric SQUID configurations by electrostatically controlling the critical currents through the junctions. This tunability allows us to study the inductances in the device, finding values of up to 2 mu H. Furthermore, we directly probe the current-phase relation of one of the junctions of the device. Our results show that complex devices in MATBG can be realized and used to reveal the properties of the material. We envision our findings, together with the established history of applications SQUIDs have(14-16), will foster the development of a wide range of devices such as phase-slip junctions(17) or high kinetic inductance detectors(18).
  • Localized detection of ions and biomolecules with a force-controlled scanning nanopore microscope
    Item type: Journal Article
    Aramesh, Morteza; Forró, Csaba; Dorwling-Carter, Livie; et al. (2019)
    Nature Nanotechnology
Publications 1 - 10 of 95