Macular Corneal Dystrophy – Molecular Genetics as the Key in Treatment-Refractory Keratopathy
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Date
2024
Publication Type
Journal Article
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yes
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Abstract
Macular corneal dystrophy (MCD) is a severe and rare form of corneal dystrophy. It usually develops in childhood or adolescence [1], [2] and is a genetic disorder with an autosomal recessive pattern of inheritance. MCD is characterized by the formation of progressive bilateral scattered gray-white punctuate opacities in the corneal stroma and central corneal thinning. It typically starts centrally, which then progressively extends to the periphery and eventually involves the entire corneal thickness. If left untreated, MCD leads to bilateral deterioration of visual acuity. Currently, the most effective treatment is corneal transplantation [1], [2]. Even though recurrence of MCD is rare, it may occur many decades after penetrating keratoplasty (PKP), which remains the gold standard in the cure of MCD for long-term visual rehabilitation.
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published
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Journal / series
Volume
241 (4)
Pages / Article No.
398 - 401
Publisher
Thieme