Nadine Lobsiger

Last Name

Lobsiger

First Name

Nadine

ORCID

0000-0002-3976-3537

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Publications 1 - 5 of 5

Strategies of Immobilizing Cells in Whole-cell Microbial Biosensor Devices Targeted for Analytical Field Applications
Lobsiger, Nadine; Stark, Wendelin J. (2019)
Analytical Sciences
YestroSens, a field-portable S. cerevisiae biosensor device for the detection of endocrine-disrupting chemicals: Reliability and stability
Lobsiger, Nadine; Venetz, Jonathan E.; Gregorini, Michele; et al. (2019)
Biosensors and Bioelectronics
A whole-cell biosensor platform and its applications in assessing environmental pollution
Lobsiger, Nadine (2020)
Continuous Production of a Shelf‐Stable Living Material as a Biosensor Platform
Schulz-Schönhagen, Konstantin; Lobsiger, Nadine; Stark, Wendelin J. (2019)
Advanced Materials Technologies
Degradation of insulin amyloid by antibiotic minocycline and formation of toxic intermediates
Mori, Wakako; Yuzu, Keisuke; Lobsiger, Nadine; et al. (2021)
Scientific Reports
Insulin balls, localized insulin amyloids formed at subcutaneous insulin-injection sites in patients with diabetes, cause poor glycemic control owing to impairments in insulin absorption. Our previous study has shown that some insulin balls are cytotoxic, but others are not, implying amyloid polymorphism. Interestingly, the patient with toxic insulin balls had been treated with antibiotic minocycline, suggesting a possible relationship between toxicity of insulin balls and minocycline. However, the direct effect of minocycline on the structure and cytotoxicity of the insulin amyloid is still unclear. Herein, we demonstrated that that minocycline at physiological concentrations induced degradation of insulin amyloids formed from human insulin and insulin drug preparations used for diabetes patients. Interestingly, the process involved the initial appearance of the toxic species, which subsequently changed into less-toxic species. It is also shown that the structure of the toxic species was similar to that of sonicated fragments of human insulin amyloids. Our study shed new light on the clarification of the revelation of insulin balls and the development of the insulin analogs for diabetes therapy.

Publications 1 - 5 of 5

Nadine Lobsiger

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