Enhancing enterocyte fatty acid oxidation in mice affects glycemic control depending on dietary fat
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Date
2018-07-17
Publication Type
Journal Article
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Abstract
Studies indicate that modulating enterocyte metabolism might affect whole body glucose homeostasis and the development of diet-induced obesity (DIO). We tested whether enhancing enterocyte fatty acid oxidation (FAO) could protect mice from DIO and impaired glycemic control. To this end, we used mice expressing a mutant form of carnitine palmitoyltransferase-1a (CPT1mt), insensitive to inhibition by malonyl-CoA, in their enterocytes (iCPT1mt) and fed them low-fat control diet (CD) or high-fat diet (HFD) chronically. CPT1mt expression led to an upregulation of FAO in the enterocytes. On CD, iCPT1mt mice had impaired glycemic control and showed concomitant activation of lipogenesis, glycolysis and gluconeogenesis in their enterocytes. On HFD, both iCPT1mt and control mice developed DIO, but iCPT1mt mice showed improved glycemic control and reduced visceral fat mass. Together these data indicate that modulating enterocyte metabolism in iCPT1mt mice affects glycemic control in a body weight-independent, but dietary fat-dependent manner.
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published
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Journal / series
Volume
8
Pages / Article No.
10818
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Subject
Fat metabolism; Type 2 diabetes
Organisational unit
09560 - De Bock, Katrien / De Bock, Katrien
09560 - De Bock, Katrien / De Bock, Katrien
Notes
Funding
153149 - Ketone bodies may link enterocyte fatty acid oxidation to eating control (SNF)