Induction of Intracellular Reductive Stress with a Photoactivatable Phosphine Probe
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Author / Creator
Date
2018-04
Publication Type
Journal Article
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yes
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Abstract
Reductive stress is a condition present in cells that have an increased concentration of reducing species, and it has been associated with a number of pathologies, such as neurodegenerative diseases and cancer. The tools available to study reductive stress lack both in selectivity and specific targeting and some of these shortcomings can be addressed by using photoactivatable compounds. We developed a photoactivatable phosphonium probe, which upon irradiation releases a fluorescent molecule and a trialkyphosphine. The probes can permeate through the plasma membrane and the photoreleased phosphine can induce intracellular reductive stress as proven by the detection of protein aggregates.
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Publication status
published
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Editor
Book title
Journal / series
Volume
72 (4)
Pages / Article No.
241 - 244
Publisher
Swiss Chemical Society
Event
Edition / version
Methods
Geographic location
Date collected
Date created
Subject
Photoactivation; Protein aggregation; Reductive stress; Tributylphosphine
Organisational unit
09551 - Rivera Fuentes, Pablo M. (ehemalig) / Rivera Fuentes, Pablo M. (former)
Notes
Funding Info about funding
165551 - Development of Intracellular Photoactivatable Probes (SNF)