1. ADVANCING DYNAMIC TRAJECTORY RADIOTHERAPY EXPLORING ROBUSTNESS FOR TREATMENT PLANNING AND MANAGING MOTION FOR DELIVERY 

   Loebner, Hannes A. (2024)

   Abstract About one in three individuals will develop cancer during their lives which makes cancer a leading cause of death. Fortunately, advances in diagnosing and treating cancer in the last century have improved patient survival and treatment outcome. Modern cancer treatment is based on three pillars. Radiotherapy, alongside surgery and chemotherapy, is prescribed to almost every second cancer patient as a single or combined treatment ...

   Doctoral Thesis

2. Robustness analysis of dynamic trajectory radiotherapy and volumetric modulated arc therapy plans for head and neck cancer 

   Loebner, Hannes A.; Bertholet, Jenny; Mackeprang, Paul-Henry; et al. (2024)

   Physics and Imaging in Radiation Oncology

   Background and purpose Dynamic trajectory radiotherapy (DTRT) has been shown to improve healthy tissue sparing compared to volumetric arc therapy (VMAT). This study aimed to assess and compare the robustness of DTRT and VMAT treatment-plans for head and neck (H&N) cancer to patient-setup (PS) and machine-positioning uncertainties. Materials and methods The robustness of DTRT and VMAT plans previously created for 46 H&N cases, prescribed ...

   Journal Article

3. Mathematical guarantees for physics-informed machine learning 

   De Ryck, Tim (2024)

   Doctoral Thesis

4. Mechanical recycling of PET containing mixtures of phosphorus flame retardants 

   Chen, Jiuke; Dul, Sithiprumnea; Lehner, Sandro; et al. (2024)

   JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

   Flame -retarded polymers, such as polyester textiles and sheets, are attracting attention with regard to their sustainability. Mechanical recycling is currently the most frequently used technique for improving the circularity of plastics. However, one complication of mechanical recycling is associated with the (still) inevitable mixtures of polymers and additives, which can influence material stability and significantly deteriorate the ...

   Journal Article

5. Ultrashort-Peptide-Responsive Gene Switches for Regulation of Therapeutic Protein Expression in Mammalian Cells 

   Huang, Jinbo; Xue, Shuai; Xie, Yu-Qing; et al. (2024)

   ADVANCED SCIENCE

   Despite the array of mammalian transgene switches available for regulating therapeutic protein expression in response to small molecules or physical stimuli, issues remain, including cytotoxicity of chemical inducers and limited biocompatibility of physical cues. This study introduces gene switches driven by short peptides comprising eight or fewer amino acid residues. Utilizing a competence regulator (ComR) and sigma factor X-inducing ...

   Journal Article

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