1. Chemical and mRNA-based Cellular Reprogramming to Muscle Progenitor Cells for the Treatment of Muscular Dystrophy 

   Qabrati, Xhem (2024)

   Muscular dystrophies encompass a group of genetic diseases with a wide spectrum of clinical severities. Duchenne muscular dystrophy (DMD) is the most common and debilitating form of dystrophy, causing progressive muscle wasting and premature death due to cardiorespiratory failure. DMD is triggered by mutations in the DMD gene that is needed to stabilize myofibers. Its absence causes perpetuating cycles of myofiber necrosis and muscle ...

   Doctoral Thesis

2. Navigating collaboration for innovation both within and across organizational boundaries: An interaction-centric perspective 

   Varesco Kager, Nora (2024)

   Innovation is crucial for firms’ long-term success, and collaboration within and across organizational boundaries is crucial for innovation, making it important to understand collaboration demands and their navigation. To do so, scholars suggested taking a holistic approach by attending to interactions between relevant elements. Yet, while collaboration elements like tensions, challenges, and success-factors have been described, there ...

   Doctoral Thesis

3. Investigating the Martian soil at the InSight landing site 

   Delage, Pierre; Caicedo, Bernardo; Golombek, Matt; et al. (2024)

   SOILS AND ROCKS

   The InSight mission is a geophysical mission aimed at better understanding the structure of Mars and of the other rocky planets of the solar system. To do so, a lander accommodating two cameras, a very sensitive seismometer, and a dynamic self -penetrating heat probe nicknamed the mole were placed on the Mars surface by the Instrument Deployment Arm (IDA). Besides geophysical data (which definitely enriched the existing knowledge on the ...

   Journal Article

4. Novel approaches for synthetic live biotherapeutic product production using immobilisation 

   Verpaalen, Mathieu (2024)

   The human gut microbiome plays an important role in health and disease and can easily be manipulated. This makes the gut microbiome a promising target for therapeutic modulation. Groups of bacteria, also called consortia, are a means to specifically enrich the gut microbiome composition with potential missing beneficial functions. However, efficient production of these synthetic consortia is challenging. The current production strategy ...

   Doctoral Thesis

5. Exploring the Utility of Graph Methods in HPC Thermal Modeling 

   Guindani, Bruno; Molan, Martin; Bartolini, Andrea; et al. (2024)

   ICPE '24 Companion: Companion of the 15th ACM/SPEC International Conference on Performance Engineering

   This work critically examines several approaches to temperature prediction for High-Performance Computing (HPC) systems, focusing on component-level and holistic models. In particular, we use publicly available data from the Tier-0 Marconi100 supercomputer and propose models ranging from a room-level Graph Neural Network (GNN) spatial model to node-level models. Our results highlight the importance of correct graph structures and suggest ...

   Conference Paper

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