Suche
Ergebnisse
-
Structural and functional characterization of two alpha-synuclein strains
(2013)Nature Communicationsα-synuclein aggregation is implicated in a variety of diseases including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy. The association of protein aggregates made of a single protein with a variety of clinical phenotypes has been explained for prion diseases by the existence of different strains that propagate through the infection pathway. Here we structurally and functionally characterize ...Journal Article -
Spatial segregation of polarity factors into distinct cortical clusters is required for cell polarity control
(2013)Nature CommunicationsCell polarity is regulated by evolutionarily conserved polarity factors whose precise higher-order organization at the cell cortex is largely unknown. Here we image frontally the cortex of live fission yeast cells using time-lapse and super-resolution microscopy. Interestingly, we find that polarity factors are organized in discrete cortical clusters resolvable to ~50–100 nm in size, which can form and become cortically enriched by ...Journal Article -
Time-resolved ultrafast photocurrents and terahertz generation in freely suspended graphene
(2012)Nature CommunicationsGraphene, a two-dimensional layer of carbon atoms, is a promising building block for a wide range of optoelectronic devices owing to its extraordinary electrical and optical properties, including the ability to absorb ~2% of incident light over a broad wavelength range. While the RC-limited bandwidth of graphene-based photodetectors can be estimated to be as large as 640 GHz, conventional electronic measurement techniques lack for analysing ...Journal Article -
Measuring single-nanoparticle wetting properties by freeze-fracture shadow-casting cryo-scanning electron microscopy
(2011)Nature CommunicationsNanoparticles at fluid interfaces are central to a rapidly increasing range of cutting-edge applications, including drug delivery, uptake through biological membranes, emulsion stabilization and the fabrication of nanocomposites. Understanding nanoscale wetting is a challenging issue, still unresolved for individual nanoparticles, and is essential in designing nanoparticle-building blocks with controlled surface properties. The core ...Journal Article -
Missing transverse energy performance of the CMS detector
(2011)Journal of InstrumentationDuring 2010 the LHC delivered pp collisions with a centre-of-mass energy of 7 TeV. In this paper, the results of comprehensive studies of missing transverse energy as measured by the CMS detector are presented. The results cover the measurements of the scale and resolution for missing transverse energy, and the effects of multiple pp interactions within the same bunch crossings on the scale and resolution. Anomalous measurements of missing ...Journal Article -
Observation of the rare Bs0 →µ+µ− decay from the combined analysis of CMS and LHCb data
(2015)NatureThe standard model of particle physics describes the fundamental particles and their interactions via the strong, electromagnetic and weak forces. It provides precise predictions for measurable quantities that can be tested experimentally. The probabilities, or branching fractions, of the strange B meson ( ) and the B0 meson decaying into two oppositely charged muons (μ+ and μ−) are especially interesting because of their sensitivity to ...Journal Article -
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
(2013)Molecular Systems BiologyTissue homeostasis is controlled by signaling systems that coordinate cell proliferation, cell growth and cell shape upon changes in the cellular environment. Deregulation of these processes is associated with human cancer and can occur at multiple levels of the underlying signaling systems. To gain an integrated view on signaling modules controlling tissue growth, we analyzed the interaction proteome of the human Hippo pathway, an ...Journal Article -
Modularity and hormone sensitivity of the Drosophila melangaster insulin receptor/target of rapamycin interaction proteome
(2011)Molecular Systems BiologyGenetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode components of the insulin receptor/target of rapamycin (InR/TOR) pathway. However, the biochemical context of this regulatory system is still poorly characterized in Drosophila. Here, we present the first quantitative study that systematically characterizes ...Journal Article -
RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42
(2011)Molecular Systems BiologyThe pathogen Salmonella Typhimurium is a common cause of diarrhea and invades the gut tissue by injecting a cocktail of virulence factors into epithelial cells, triggering actin rearrangements, membrane ruffling and pathogen entry. One of these factors is SopE, a G‐nucleotide exchange factor for the host cellular Rho GTPases Rac1 and Cdc42. How SopE mediates cellular invasion is incompletely understood. Using genome‐scale RNAi screening ...Journal Article -
Frequent floods in the European Alps coincide with cooler periods of the past 2500 years
(2013)Scientific ReportsSevere floods triggered by intense precipitation are among the most destructive natural hazards in Alpine environments, frequently causing large financial and societal damage. Potential enhanced flood occurrence due to global climate change would thus increase threat to settlements, infrastructure, and human lives in the affected regions. Yet, projections of intense precipitation exhibit major uncertainties and robust reconstructions of ...Journal Article