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Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum
(2009)The Journal of Cell BiologyTo maintain protein homeostasis in secretory compartments, eukaryotic cells harbor a quality control system that monitors protein folding and protein complex assembly in the endoplasmic reticulum (ER). Proteins that do not fold properly or integrate into cognate complexes are degraded by ER-associated degradation (ERAD) involving retrotranslocation to the cytoplasm and proteasomal peptide hydrolysis. N-linked glycans are essential in ...Journal Article