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Evolution and functional cross-talk of protein post-translational modifications
(2013)Molecular Systems BiologyProtein post-translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of the evolution and function of PTMs that were ...Journal Article -
Potential release scenarios for carbon nanotubes used in composites
(2013)Environment InternationalThe expected widespread use of carbon nanotube (CNT)-composites in consumer products calls for an assessment of the possible release and exposure to workers, consumers and the environment. Release of CNTs may occur at all steps in the life cycle of products, but to date only limited information is available about release of CNTs from actual products and articles. As a starting point for exposure assessment, exploring sources and pathways ...Journal Article -
The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection
(2013)mBioThe intestinal tract is the largest reservoir of microbes in the human body. The intestinal microbiota is thought to be able to modulate alterations of the gut induced by enteropathogens, thereby maintaining homeostasis. Listeria monocytogenes is the agent of listeriosis, an infection transmitted to humans upon ingestion of contaminated food. Crossing of the intestinal barrier is a critical step of the infection before dissemination ...Journal Article -
How Eco-Efficient Are Low-Input Cropping Systems in Western Europe, and What Can Be Done to Improve Their Eco-Efficiency
(2013)SustainabilityLow-input cropping systems were introduced in Western Europe to reduce the environmental impacts of intensive farming, but some of their benefits are offset by lower yields. In this paper, we review studies that used Life Cycle Assessment (LCA) to investigate the effects of reducing external inputs on the eco-efficiency of cropping systems, measured as the ratio of production to environmental impacts. We also review various cropping system ...Journal Article -
The Modern Phosphorus Sustainability Movement
(2013)SustainabilitySince the “peak phosphorus” concept emerged in 2007, concerns about the future availability of phosphate rock have funneled into a growing number of actions, often in the form of new and innovative platforms focusing on phosphorus sustainability. This trend seems to continue on different levels and in different formats, which makes the landscape of activities increasingly blurred and complex. This article considers the emerging phase of ...Journal Article -
System Design and Analysis of a Directly Air-Assisted Turbocharged SI Engine with Camshaft Driven Valves
(2013)EnergiesThe availability of compressed air in combination with downsizing and turbocharging is a promising approach to improve the fuel economy and the driveability of internal combustion engines. The compressed air is used to boost and start the engine. It is generated during deceleration phases by running the engine as a piston compressor. In this paper, a camshaft-driven valve is considered for the control of the air exchange between the tank ...Journal Article -
Single-cell lysis for visual analysis by electron microscopy
(2013)Journal of Structural BiologyThe stochastic nature of biological systems makes the study of individual cells a necessity in systems biology. Yet, handling and disruption of single cells and the analysis of the relatively low concentrations of their protein components still challenges available techniques. Transmission electron microscopy (TEM) allows for the analysis of proteins at the single-molecule level. Here, we present a system for single-cell lysis under light ...Journal Article -
The constant beat: cardiomyocytes adapt their forces by equal contraction upon environmental stiffening
(2013)Biology OpenCardiomyocytes are responsible for the permanent blood flow by coordinated heart contractions. This vital function is accomplished over a long period of time with almost the same performance, although heart properties, as its elasticity, change drastically upon aging or as a result of diseases like myocardial infarction. In this paper we have analyzed late rat embryonic heart muscle cells' morphology, sarcomere/costamere formation and ...Journal Article -
Hybrid-Electric Vehicle with Natural Gas-Diesel Engine
(2013)EnergiesAbstract In this paper we demonstrate the potential of combining electric hybridization with a dual-fuel natural gas-Diesel engine. We show that carbon dioxide emissions can be reduced to 43 gram per kilometer with a subcompact car on the New European Driving Cycle (NEDC). The vehicle is operated in charge-sustaining mode, which means that all energy is provided by the fuel. The result is obtained by hardware-in-the-loop experiments where ...Journal Article -
Intake Manifold Boosting of Turbocharged Spark-Ignited Engines
(2013)EnergiesDownsizing and turbocharging is a widely used approach to reduce the fuel consumption of spark ignited engines while retaining the maximum power output. However, a substantial loss in drivability must be expected due to the occurrence of the so-called turbo lag. The turbo lag results from the additional inertia that the turbocharger adds to the system. Supplying air by an additional valve, the boost valve, to the intake manifold can be ...Journal Article