Repurposing de novo designed entities reveals phosphodiesterase 3B and cathepsin L modulators
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Autor(in)
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Datum
2015-05-01Typ
- Journal Article
ETH Bibliographie
yes
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Abstract
Using computational bioactivity prediction models we identified phosphodiesterase 3B (PDE3B) and cathepsin L as macromolecular targets of de novo designed compounds. By disclosing the most potent cathepsin L activator known to date, small molecule repurposing by target panel prediction represents a feasible route towards innovative leads for chemical biology and molecular medicine. Mehr anzeigen
Persistenter Link
https://doi.org/10.3929/ethz-b-000101107Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Chemical CommunicationsBand
Seiten / Artikelnummer
Verlag
Royal Society of ChemistryOrganisationseinheit
03852 - Schneider, Gisbert / Schneider, Gisbert
ETH Bibliographie
yes
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