Open access
Date
2017-02Type
- Review Article
Abstract
Learning and memory are dependent on interactive excitatory and inhibitory mechanisms. In this review, we discuss a mechanism called disinhibition, which is the release of an inhibitory constraint that effectively results in an increased activity in the target neurons (for example, principal or projection neurons). We focus on discussing the role of disinhibition in learning and memory at a basic level and in disease models with cognitive deficits and highlight a strategy to reverse cognitive deficits caused by excess inhibition, through disinhibition of α5-containing GABAA receptors mediating tonic inhibition in the hippocampus, based on subtype-selective negative allosteric modulators as a novel class of drugs. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000129138Publication status
publishedExternal links
Journal / series
F1000ResearchVolume
Pages / Article No.
Publisher
F1000ResearchSubject
Pavlovian learning; disinhibition; somatostatin; GABAA; allosteric modulatorsMore
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