Stem-cell-associated structural and functional plasticity in the aging hippocampus
Metadata only
Datum
2008Typ
- Journal Article
ETH Bibliographie
yes
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Abstract
Aging frequently leads to a functional decline across multiple cognitive domains, often resulting in a severe reduction in life quality and also causing substantial care-related costs. Understanding age-associated structural and functional changes of neural circuitries within the brain is required to improve successful aging. In this review, the authors focus on age-dependent alterations of the hippocampus and the decline of hippocampal function, which are critically involved in processes underlying certain forms of learning and memory. Despite the dramatic reductions in hippocampus-dependent function that accompany advancing age, there is also striking evidence that even the aged brain retains a high level of plasticity. Thus, one promising avenue to reach the goal of successful aging might be to boost and recruit this plasticity, which is the interplay between neural structure, function, and experience, to prevent age-related cognitive decline and age-associated comorbidities. Mehr anzeigen
Publikationsstatus
publishedExterne Links
Zeitschrift / Serie
Psychology and AgingBand
Seiten / Artikelnummer
Verlag
American Psychological AssociationOrganisationseinheit
03776 - Jessberger, Sebastian03367 - Suter, Ulrich / Suter, Ulrich
ETH Bibliographie
yes
Altmetrics