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Gene-targeted identification of DNA lesions to unravel mechanisms of mutagenesis
(2019)Doctoral Thesis -
Material- and Fabrication-informed Design of Structurally-sound Jammed Architectural Structures
(2019)In the last two decades an increasing number of professionals and researchers have attempted to minimise the harmful impact of the building industry on the environment by taking advantage of ongoing technological progress. Computational design and digital fabrication technology are combined to realise geometrically or functionally complex architectural artefacts. As a result, optimised material use can be achieved. Nevertheless, in the ...Doctoral Thesis -
Data-driven uncertainty quantification for high-dimensional engineering problems
(2019)In the context of complex industrial systems and civil infrastructures, taking into account uncertainties during the design process has received much attention in the last decades. Although there is significant progress in modelling such systems, there are always discrepancies between ideal in-silico designed systems and real-world manufactured ones. Starting from a realistic computational model that reproduces the behaviour of an ...Doctoral Thesis -
Dissipation and Interactions in Quantum Optics
(2019)Quantum optics, the study of light at the level of its building blocks, has been one of the frontiers of science. The arena of quantum optics has been fruitful for investigations of a wide range of interesting questions, from those on the fundamental structures in driven dissipative systems to those on applications of quantum information processing and quantum communication. The first part of this thesis is concerned with one of the ...Doctoral Thesis -
Trust in Digital Health
(2019)This thesis contributes to our understanding of the strategies and features necessary to build and maintain trust in digital health. Myriad experts foresee digital health technologies as a solution to alleviate the demands on contemporary health systems. Yet, these technologies introduce many ethical challenges, one of which is trust. Besides altering the status quo in physician-patient relationships, plenty of evidence suggests that ce ...Doctoral Thesis -
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Coherent spin dynamics in optically excited antiferromagnets
(2019)Antiferromagnetic spintronics emerged in the last decade as a promising approach to overcome limitations of current information technology. Owing to the vanishing net magnetization, antiferromagnetic materials exhibit spin dynamics on sub-picosecond timescales potentially allowing not only for data storage and logic circuit applications that are orders of magnitude faster than their established ferromagnetic counterparts, but also the ...Doctoral Thesis -
High-Throughput Detection and Functional Classification of Retinal Ganglion Cells using High-Density Microelectrode Arrays
(2019)This thesis presents a label-free method to detect and func- tionally characterize hundreds of retinal ganglion cells (RGC) simultaneously. The approach relies on measuring the extra- cellular action potentials of RGCs using high-density micro- electrode arrays (HD-MEA) while projecting light stimuli onto the photoreceptor layer of ex vivo retinae. Our HD-MEA system features an electrode density similar to the density of mouse RGCs (~3300 ...Doctoral Thesis