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The Physiological Landscape and Specificity of Antibody Repertoires
(2021)bioRxivDiverse antibody repertoires spanning multiple lymphoid organs (e.g., bone marrow, spleen, lymph nodes) form the foundation of protective humoral immunity. Changes in their composition across lymphoid organs are a consequence of B-cell selection and migration events leading to a highly dynamic and unique physiological landscape of antibody repertoires upon antigenic challenge (e.g., vaccination). However, to what extent B cells encoding ...Working Paper -
B cell clonal expansion is correlated with antigen-specificity in young but not old mice
(2021)bioRxivAging of the humoral immune response has been shown to affect its critical role in defending the host from a variety of pathogens. Technical limitations have nevertheless made it challenging to investigate the relationship between genotype and phenotype of antibody repertoires in the context of aging. We therefore performed single-cell sequencing of over 95,000 B cells to simultaneously investigate B cell receptor (BCR) repertoires and ...Working Paper -
Comment on "A literature review and meta-analysis of the effects of lockdowns on COVID-19 mortality"
(2022)In a recent working paper, Herby et al. conduct a systematic review and meta-analysis of the effects of lockdowns on COVID-19 mortality. Based on their results, they conclude that "lockdowns have had little to no public health effects'' and that "lockdowns should be rejected out of hand as a pandemic policy instrument'' (p. 2). These strong conclusions have quickly been taken up by the public media. Here, we would like to comment on the ...Working Paper -
Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells
(2021)bioRxivThe capacity of humoral B cell-mediated immunity to effectively respond to and protect against pathogenic infections is largely driven by the presence of a diverse repertoire of polyclonal antibodies in the serum, which are produced by plasma cells (PCs).1,2 Recent studies have started to reveal the balance between deterministic mechanisms and stochasticity of antibody repertoires on a genotypic level (i.e., clonal diversity, somatic ...Working Paper -
Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections
(2021)bioRxivCD8+ T cells play a crucial role in the control and resolution of viral infections and can adopt a wide range of phenotypes and effector functions depending on the inflammatory context and the duration and extent of antigen exposure. Similarly, viral infections can exert diverse selective pressures on populations of clonally related T cells. Technical limitations have nevertheless made it challenging to investigate the relationship between ...Working Paper -
A new theoretical framework jointly explains behavioral and neural variability across subjects performing flexible decision-making
(2022)bioRxivThe ability to flexibly select and accumulate relevant information to form decisions, while ignoring irrelevant information, is a fundamental component of higher cognition. Yet its neural mechanisms remain unclear. Here we demonstrate that, under assumptions supported by both monkey and rat data, the space of possible network mechanisms to implement this ability is spanned by the combination of three different components, each with specific ...Working Paper -
Techno-Economic Assessment & Life Cycle Assessment Guidelines for CO2 Utilization (Version 2.0)
(2022)Climate change is one of the greatest challenges of our time. Under the auspices of the UN Framework Convention on Climate Change and through the Paris Agreement, there is a commitment to keep global temperature rise this century to well below two degrees Celsius compared with pre-industrial levels. This will require a variety of strategies, including increased renewable power generation, broad-scale electrification, greater energy ...Report -
The Chloroflexi supergroup is metabolically diverse and representatives have novel genes for non-photosynthesis based CO2 fixation
(2021)bioRxivThe Chloroflexi superphylum have been investigated primarily from the perspective of reductive dehalogenation of toxic compounds, anaerobic photosynthesis and wastewater treatment, but remain relatively little studied compared to their close relatives within the larger Terrabacteria group, including Cyanobacteria, Actinobacteria, and Firmicutes. Here, we conducted a detailed phylogenetic analysis of the phylum Chloroflexota, the ...Working Paper -
Database for design-compatible waveforms
(2023)Abstract on selection of ground motions for microzonation. We have analyzed and compared the stations metadata of three strong motion databases: KiK-net (Japan), ESM (Europe and Middle East), and NGA-West2 (USA). For each data-base, we propose a subset of stations suitable for the purposes of the project. These sub-sets of stations comprise 772 sites classified in terms of SIA261 (2020) soil categories (A-E), inspecting the provided VS ...Report -
The Robotic Herd: Using Human-Bot Interactions to Explore Irrational Herding
(2023)SocArXivWe explore human herding in a strategic setting where humans interact with automated entities (bots) and study the shift in the behavior and beliefs of humans when they are aware of interacting with bots. The strategic setting is an online minority game, where 1,997 participants are rewarded for following the minority strategy. This setting permits distinguishing between irrational herding and rational self-interesta fundamental challenge ...Working Paper