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Deep learning-guided selection of antibody therapies with enhanced resistance to current and prospective SARS-CoV-2 Omicron variants
(2023)bioRxivMost COVID-19 antibody therapies rely on binding the SARS-CoV-2 receptor binding domain (RBD). However, heavily mutated variants such as Omicron and its sublineages, which are characterized by an ever increasing number of mutations in the RBD, have rendered prior antibody therapies ineffective, leaving no clinically approved antibody treatments for SARS-CoV-2. Therefore, the capacity of therapeutic antibody candidates to bind and neutralize ...Working Paper -
Morphometry and mechanical instability at the onset of epithelial bladder cancer
(2023)bioRxivMalignancies of epithelial tissues, called carcinomas, account for the majority of cancer cases. Much cancer research has focused on genetic alterations and their relation to different carcinoma phenotypes. Besides a rewiring in the signalling networks, carcinoma progression is accompanied by mechanical changes in the epithelial cells and the extracellular matrix. Here, we reveal intricate morphologies in the basement membrane at the onset ...Working Paper -
Success factors of growth-stage digital health companies: protocol for a systematic literature review
(2024)medRxivBackground The healthcare industry is undergoing rapid transformation and progress, fueled by technological advances and the growing need for accessible, affordable, and high-quality healthcare services. While there has been significant progress in digitizing healthcare, especially during the COVID-19 pandemic, there is still considerable untapped potential for digital therapeutics (DTx). According to a report by Bloomberg, the digital ...Working Paper -
reComBat: Batch effect removal in large-scale, multi-source omics data integration
(2021)bioRxivWith the steadily increasing abundance of omics data produced all over the world, some-times decades apart and under vastly different experimental conditions residing in public databases, a crucial step in many data-driven bioinformatics applications is that of data integration. The challenge of batch effect removal for entire databases lies in the large number and coincide of both batches and desired, biological variation resulting in ...Working Paper -
Modelling life cycle costs for edge beams of three Norwegian bridges
(2022)NPRA ReportsFor the planning of cost-effective infrastructure maintenance, it is important to assess the condition of structures and to estimate the optimum time, the extent and the type of repair needed to continue operating the structures safely. In this study, a novel approach is presented, which combines data from condition assessment of reinforced concrete structures (e.g. chloride profiles), predictive modelling (future chloride ingress) and ...Report