Search
Results
-
Lack of evidence that ursodeoxycholic acids effects on the gut microbiome influence colorectal adenoma risk
(2017)bioRxivObjective We previously reported that Ursodeoxycholic acid (UDCA), a therapeutic bile acid, reduces risk for advanced colorectal adenoma in men but not women. Interactions between the gut microbiome and fecal bile acid composition as a factor in colon cancer neoplasia have been postulated but evidence is limited to small cohorts and animal studies. Design Using banked stool samples collected as part of a phase III randomized clinical ...Working Paper