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Final Report: Energy security in scenarios for Europe's future electricity supply
(2012)SEFEP Working PaperWorking Paper -
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A missense variant effect prediction and annotation resource for SARS-CoV-2
(2021)bioRxivThe COVID19 pandemic is a global crisis severely impacting many people across the world. An important part of the response is monitoring viral variants and determining the impact they have on viral properties, such as infectivity, disease severity and interactions with drugs and vaccines. In this work we generate and make available computational variant effect predictions for all possible single amino-acid substitutions to SARS-CoV-2 in ...Working Paper -
Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival
(2021)bioRxivGenetic alterations in cancer cells trigger oncogenic transformation, a process largely mediated by the dysregulation of kinase and transcription factor (TF) activities. While the mutational profiles of thousands of tumours has been extensively characterized, the measurements of protein activities has been technically limited until recently. We compiled public data of matched genomics and (phospho)proteomics measurements for 1,110 tumours ...Working Paper -
Climate Shocks, Cyclones, and Economic Growth: Bridging the Micro-Macro Gap
(2018)NBER Working Paper SeriesEmpirical analyses of the impacts of climatic shocks on growth, while critical for policy, have found seemingly disparate results and are seldom incorporated into macroeconomic climate economy models. This paper seeks to bridge this micro-macro gap through the case of tropical cyclones. We first present a stochastic endogenous growth model that can reconcile previous empirical findings. We then empirically estimate the impacts of cyclones ...Working Paper -
Do disasters affect growth? A macro model-based perspective on the empirical debate
(2016)Bravo Center Faculty Working Paper SeriesWorking Paper -
Nektar++: Design and implementation of an implicit, spectral/hp element, compressible flow solver using a Jacobian-free Newton Krylov approach
(2020)arXivAt high Reynolds numbers, the use of explicit in time compressible flow simulations with spectral/hp element discretization can become significantly limited by time step. To alleviate this limitation we extend the capability of the spectral/hp element open-source software framework, Nektar++, to include an implicit discontinuous Galerkin compressible flow solver. The integration in time is carried out by a singly diagonally implicit ...Working Paper -
Network expansion of genetic associations defines a pleiotropy map of human cell biology
(2021)bioRxivProteins that interact within molecular networks tend to have similar functions and when perturbed influence the same organismal traits. Interaction networks can be used to expand the list of likely trait associated genes from genome-wide association studies (GWAS). Here, we used improvements in SNP-to-gene mapping to perform network based expansion of trait associated genes for 1,002 human traits showing that this recovers known disease ...Working Paper -
Hydrologic predictions in a changing environment: behavioral modeling
(2010)Hydrology and Earth System Sciences DiscussionsMost hydrological models are valid at most only in a few places and cannot be rea-sonably transferred to other places or to far distant time periods. Transfer in space isdifficult because the models are conditioned on past observations at particular placesto define parameter values and unobservable processes that are needed to fully characterize the structure and functioning of the landscape. Transfer in time has to deal withthe likely ...Working Paper -
Electricity Planning for Sustainable Development in the MENA Region
(2017)MENA-SELECT Working PaperWorking Paper