Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics
dc.contributor.author
Sonousi, Amr
dc.contributor.author
Sarpe, Dirk
dc.contributor.author
Brilkova, Margarita
dc.contributor.author
Schacht, Jochen
dc.contributor.author
Vasella, Andrea
dc.contributor.author
Böttger, Erik C.
dc.contributor.author
Crich, David
dc.date.accessioned
2018-08-13T13:02:48Z
dc.date.available
2018-06-08T06:43:38Z
dc.date.available
2018-06-18T14:29:18Z
dc.date.available
2018-08-13T13:02:48Z
dc.date.issued
2018-07-13
dc.identifier.issn
2373-8227
dc.identifier.other
10.1021/acsinfecdis.8b00052
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/268364
dc.language.iso
en
en_US
dc.publisher
American Chemical Society
en_US
dc.subject
aminoglycosides
en_US
dc.subject
structure-activity relationship
en_US
dc.subject
minoglycoside-modifying enzymes
en_US
dc.subject
ribosomal methyltransferases
en_US
dc.subject
cell-free translation assays
en_US
dc.title
Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics
en_US
dc.type
Journal Article
dc.date.published
2018-04-30
ethz.journal.title
ACS Infectious Diseases
ethz.journal.volume
4
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
ACS Infect Dis
ethz.pages.start
1114
en_US
ethz.pages.end
1120
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Columbus, OH
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2018-06-08T06:43:52Z
ethz.source
SCOPUS
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2018-08-13T13:02:50Z
ethz.rosetta.lastUpdated
2022-03-28T21:01:03Z
ethz.rosetta.versionExported
true
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Journal Article [128972]