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Hubble Space Telescope GOODS NICMOS Survey
(2013)We present the details and early results from a deep near-infrared survey utilizing the NICMOS instrument on the Hubble Space Telescope centred around massive M*>1011M☉ galaxies at 1.7<z<2.9 found within the Great Observatories Origins Deep Survey (GOODS) fields North and South. The GOODS NICMOS Survey (GNS) was designed to obtain deep F160W (H-band) imaging of 80 of these massive galaxies and other colour-selected objects such as Lyman-break ...Data Collection -
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Whole genome microarray gene expression profiling of hippocampal genes from aged rats subjected to chronic unpredictable mild stress
(2015)Psychological, psychosocial and physical stress are major risk factors, which enhance the development of sporadic late-onset Alzheimer`s disease. The chronic unpredictable mild stress model mimics those risk factors and triggers signs of neurodegeneration and neuropathological features of sporadic AD such as tau hyperphosphorylation and enhanced amyloid beta generation. The study investigated the impact of chronic unpredictable mild stress ...Dataset -
Microarray gene expression profiling of heart failure induced in apolipoprotein E-deficient mice
(2011)The anti-diabetic drug and agonist of the peroxisome proliferator-activated receptor gamma (Pparg), rosiglitazone, was recently withdrawn in many countries because the drug use was associated with an increased risk of heart failure. To investigate underlying pathomechanisms, we chose 6-month-old apolipoprotein E (apoE)-deficient mice, which are prone to atherosclerosis and insulin resistance, and thereby mimic the risk profile of patients ...Dataset -
Cardiac gene expression profiling of heart failure treatment with the anti-ischemic drug ranolazine
(2010)Heart failure is a leading cause of cardiovascular mortality with limited options for treatment. We analyzed whether the anti-ischemic drug ranolazine could retard the progression of heart failure in an experimental model of heart failure induced by 6 months of chronic pressure overload. The study showed that 2 months of ranolazine treatment improved cardiac function of aortic constricted C57BL/6J (B6) mice with symptoms of heart failure ...Dataset -
Hippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
(2013)Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in protein level and activity of the angiotensin-converting enzyme (ACE). ACE inhibitors are a widely used class of drugs with established benefits ...Dataset