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Wind-driven rain on two parallel wide buildings: Field measurements and CFD simulations
(2015)Journal of Wind Engineering and Industrial AerodynamicsJournal Article -
H. pylori-Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-kappaB Target Gene Expression
(2015)Cell ReportsThe human bacterial pathogen Helicobacter pylori exhibits genotoxic properties that promote gastric carcinogenesis. H. pylori introduces DNA double strand breaks (DSBs) in epithelial cells that trigger host cell DNA repair efforts. Here, we show that H. pylori-induced DSBs are repaired via error-prone, potentially mutagenic non-homologous end-joining. A genome-wide screen for factors contributing to DSB induction revealed a critical role ...Journal Article -
Distal and proximal controls on the silicon stable isotope signature of North Atlantic Deep Water
(2015)Earth and Planetary Science LettersIt has been suggested that the uniquely high δ30Si signature of North Atlantic Deep Water (NADW) results from the contribution of isotopically fractionated silicic acid by mode and intermediate waters that are formed in the Southern Ocean and transported to the North Atlantic within the upper limb of the meridional overturning circulation (MOC). Here, we test this hypothesis in a suite of ocean general circulation models (OGCMs) with ...Journal Article -
Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner
(2015)Neurobiology of AgingEarly uptake of [11C]-Pittsburgh Compound B (ePiB, 0–6 minutes) estimates cerebral blood flow. We studied ePiB in 13 PiB-negative and 10 PiB-positive subjects with mild cognitive impairment (MCI, n = 23) and 11 PiB-positive and 74 PiB-negative cognitively healthy elderly control subjects (HCS, n = 85) in 6 bilateral volumes of interest: posterior cingulate cortex (PCC), hippocampus (hipp), temporoparietal region, superior parietal gyrus, ...Journal Article -
An ecological economic assessment of risk-reducing effects of species diversity in managed grasslands
(2015)Ecological EconomicsJournal Article -
Intercomparison of dissolved trace elements at the Bermuda Atlantic Time Series station
(2015)Marine ChemistryJournal Article -
GEMSFITS: Code package for optimization of geochemical model parameters and inverse modeling
(2015)Applied GeochemistryJournal Article -
Impact and mitigation of borehole related effects in permanent crosshole resistivity imaging: An example from the Ketzin CO2 storage site
(2015)Journal of Applied GeophysicsGeoelectrical methods are particularly suited for CO2 injection monitoring due to their high sensitivity to fluid displacement processes in porous rock formations. The use of borehole electrodes is favorable for deep storage horizons. Yet data acquisition based on permanently installed borehole electrodes can be challenged by the finite extent of the electrodes, unintended borehole deviation and complex borehole completion. Such conditions ...Journal Article -
Valve's organization: Opportunities and open questions
(2015)Journal of Organization DesignValve is a very interesting case study! The company shares many features with open source software projects. In Valve, as in the open source world, the focus is on creating advanced technologies and letting developers self-select projects and tasks. Self-selection seems to work particularly well in an environment where technology development itself has a coordinating function. In software development, people have a strong bond of common ...Journal Article -
Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein
(2015)eBioMedicineWe have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice. Therefore, Taspase1 represents a conditional oncoprotein in the context of t(4;11) leukemia. In this report, we used site-directed mutagenesis to unravel the molecular events by which Taspase1 becomes sequentially activated. ...Journal Article