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The Impossibility of Conservatism? Insights from Russian History
(2016)The MonistThis essay argues that both the normative worth and practicality of conservatism depend on how much there is to enjoy and value in actual historical circumstances. I use examples from Russian history in the Tsarist period to show that if they live in times of great hardship, or under arbitrary political rule, political actors and thinkers with conservative sympathies (such as respect for tradition, and predilection for slow, gradual ...Journal Article -
Maximizing the benefits and minimizing the risks of intervention programs to address micronutrient malnutrition: Symposium report
(2016)Maternal & Child NutritionInterventions to address micronutrient deficiencies have large potential to reduce the related disease and economic burden. However, the potential risks of excessive micronutrient intakes are often not well determined. During the Global Summit on Food Fortification, 9–11 September 2015, in Arusha, a symposium was organized on micronutrient risk–benefit assessments. Using case studies on folic acid, iodine and vitamin A, the presenters ...Journal Article -
The small RNA SraG participates in PNPase homeostasis
(2016)RNAThe rpsO-pnp operon encodes ribosomal protein S15 and polynucleotide phosphorylase, a major 3′–5′ exoribonuclease involved in mRNA decay in Escherichia coli. The gene for the SraG small RNA is located between the coding regions of the rpsO and pnp genes, and it is transcribed in the opposite direction relative to the two genes. No function has been assigned to SraG. Multiple levels of post-transcriptional regulation have been demonstrated ...Journal Article -
Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through sonic hedgehog
(2016)Genes & DevelopmentGrowth and regeneration of one tissue within an organ compels accommodative changes in the surrounding tissues. However, the molecular nature and operating logic governing these concurrent changes remain poorly defined. The dermal adipose layer expands concomitantly with hair follicle downgrowth, providing a paradigm for studying coordinated changes of surrounding lineages with a regenerating tissue. Here, we discover that hair follicle ...Journal Article -
Structure of a human pre-40S particle points to a role for RACK1 in the final steps of 18S rRNA processing
(2016)Nucleic Acids ResearchSynthesis of ribosomal subunits in eukaryotes is a complex and tightly regulated process that has been mostly characterized in yeast. The discovery of a growing number of diseases linked to defects in ribosome biogenesis calls for a deeper understanding of these mechanisms and of the specificities of human ribosome maturation. We present the 19 Å resolution cryo-EM reconstruction of a cytoplasmic precursor to the human small ribosomal ...Journal Article -
Complementary-addressed site-directed spin labeling of long natural RNAs
(2016)Nucleic Acids ResearchNanoscale distance measurements by pulse dipolar Electron paramagnetic resonance (EPR) spectroscopy allow new insights into the structure and dynamics of complex biopolymers. EPR detection requires site directed spin labeling (SDSL) of biomolecule(s), which remained challenging for long RNAs up-to-date. Here, we demonstrate that novel complementary-addressed SDSL approach allows efficient spin labeling and following structural EPR studies ...Journal Article -
Satellite tidal magnetic signals constrain oceanic lithosphere-asthenosphere boundary
(2016)Science AdvancesThe tidal flow of electrically conductive oceans through the geomagnetic field results in the generation of secondary magnetic signals, which provide information on the subsurface structure. Data from the new generation of satellites were shown to contain magnetic signals due to tidal flow; however, there are no reports that these signals have been used to infer subsurface structure. We use satellite-detected tidal magnetic fields to image ...Journal Article -
Independent component processes underlying emotions during natural music listening
(2016)Social Cognitive and Affective NeuroscienceThe aim of this study was to investigate the brain processes underlying emotions during natural music listening. To address this, we recorded high-density electroencephalography (EEG) from 22 subjects while presenting a set of individually matched whole musical excerpts varying in valence and arousal. Independent component analysis was applied to decompose the EEG data into functionally distinct brain processes. A k-means cluster analysis ...Journal Article -
How Good Are Statistical Models at Approximating Complex Fitness Landscapes?
(2016)Molecular Biology and EvolutionFitness landscapes determine the course of adaptation by constraining and shaping evolutionary trajectories. Knowledge of the structure of a fitness landscape can thus predict evolutionary outcomes. Empirical fitness landscapes, however, have so far only offered limited insight into real-world questions, as the high dimensionality of sequence spaces makes it impossible to exhaustively measure the fitness of all variants of biologically ...Journal Article -
The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts
(2016)Nucleic Acids ResearchEnzymatic approaches for locating alkylation adducts at single-base resolution in DNA could enable new technologies for understanding carcinogenesis and supporting personalized chemotherapy. Artificial nucleotides that specifically pair with alkylated bases offer a possible strategy for recognition and amplification of adducted DNA, and adduct-templated incorporation of an artificial nucleotide has been demonstrated for a model DNA adduct ...Journal Article