Suche
Ergebnisse
-
Timing, Thrusting Mode, and Negative Inversion Along the Circeo Thrust, Apennines, Italy: How the Accretion-To-Extension Transition Operated During Slab Rollback
(2023)TectonicsThe evolution of the Apennine wedge has seen the time-space migration of the forebulge, foredeep, thrust wedge, and back-arc extension phases in the wake of the Eastward rollback of the subducting Adria slab. In this framework, thrusting and post-orogenic extensional faulting have occurred in two parallel forelandward-migrating ribbons, with extensional deformation overprinting or partly exploiting anisotropies of the inherited thrust ...Journal Article -
VISITOR: Visual Interactive State Sequence Exploration for Reinforcement Learning
(2023)Computer Graphics ForumUnderstanding the behavior of deep reinforcement learning agents is a crucial requirement throughout their development. Existing work has addressed the identification of observable behavioral patterns in state sequences or analysis of isolated internal representations; however, the overall decision-making of deep-learning RL agents remains opaque. To tackle this, we present VISITOR, a visual analytics system enabling the analysis of entire ...Journal Article -
Hypocenter-Based 3D Imaging of Active Faults: Method and Applications in the Southwestern Swiss Alps
(2023)Journal of Geophysical Research: Solid EarthDespite the fact that earthquake occurrence can be strongly influenced by the architecture of pre-existing faults, it remains challenging to obtain information about the detailed subsurface geometries of active fault systems. Current geophysical methods for studying such systems often fail to resolve geometrical complexities at sufficiently high spatial resolutions. In this work, we present a novel method for imaging the detailed 3D ...Journal Article -
Developing and Extending Status Prediction Models for Railway Tracks Based on On-Board Monitoring Data
(2023)Transportation Research RecordAssigning inspection trains to monitor track quality is a standard procedure for maintaining railway system safety. The main challenges lie in lacking time and resources to perform the inspections because of the increasing traffic nowadays. To overcome these challenges, many consider adopting the on-board monitoring (OBM) technique for performing the inspections. This technique assigns commercial trains, instead of traditional track ...Journal Article -
Multiple Large-Scale Dynamical Pathways for Pan–Atlantic Compound Cold and Windy Extremes
(2023)Geophysical Research LettersWinter cold spells over North America have been correlated with European wind extremes, but the physical mechanisms behind such “pan-Atlantic” compound extremes have not been clarified yet. In this study, we propose that pan–Atlantic cold and windy extremes occur following two possible dynamical pathways. The first one involves the propagation of a Rossby wave train from the Pacific Ocean, associated with windstorms over north-western ...Journal Article -
A Water- and Base-Stable Iminopyridine-Based Cage That Can Bind Larger Organic Anions
(2023)European Journal of Inorganic ChemistryCatalysis inside molecular cages and capsules has attracted an increasing amount of attention over the last decade. While many examples of the catalysis of reactions with cationic intermediates and transition states are known, those with anionic counterparts are scarce. One limiting factor is access to suitably sized cationic iminopyridine-based cages that are stable towards water and anionic/nucleophilic guest molecules. This study aimed ...Journal Article -
BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility
(2023)Nucleic Acids ResearchThe transcription factor BTB and CNC homology 1(BACH1) has been linked to coronary artery disease risk by human genome-wide association studies, but little is known about the role of BACH1 in vascular smooth muscle cell (VSMC) phenotype switching and neointima formation following vascular injury. Therefore, this study aims to explore the role of BACH1 in vascular remodeling and its underlying mechanisms. BACH1 was highly expressed in human ...Journal Article -
A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2
(2023)Nucleic Acids ResearchThe pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new insights into the biology of betacoronaviruses to inform drug screening and development. Here, we establish a workflow to determine the RNA recognition and druggability of the nucleocapsid N-protein of SARS-CoV-2, a highly abundant protein crucial for the viral life cycle. We use a synergistic method that combines NMR spectroscopy and protein-RNA cross-linking ...Journal Article -
Seismic Constraints on Damage Growth Within an Unstable Hanging Glacier
(2023)Geophysical Research LettersForecasting hanging glacier instabilities remain challenging as sensing technology focusing on the ice surface fails to detect englacial damage leading to large-scale failure. Here, we combine icequake cluster analysis with coda wave interferometry constraining damage growth on Switzerland's Eiger hanging glacier before a 15,000 m3 break-off event. The method focuses on icequake migration within clusters rather than previously proposed ...Journal Article -
A Synthetic Dynamic Polyvinyl Alcohol Photoresin for Fast Volumetric Bioprinting of Functional Ultrasoft Hydrogel Constructs
(2023)Advanced Functional MaterialsTomographic volumetric bioprinting (VBP) enables fast photofabrication of cell-laden hydrogel constructs in one step, addressing the limitations of conventional layer-by-layer additive manufacturing. However, existing biomaterials that fulfill the physicochemical requirements of VBP are limited to gelatin-based photoresins of high polymer concentrations. The printed microenvironments are predominantly static and stiff, lacking sufficient ...Journal Article