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SnTox3 acts in effector triggered susceptibility to induce disease on wheat carrying the Snn3 gene
(2009)PLoS PathogensThe necrotrophic fungus Stagonospora nodorum produces multiple proteinaceous host-selective toxins (HSTs) which act in effector triggered susceptibility. Here, we report the molecular cloning and functional characterization of the SnTox3-encoding gene, designated SnTox3, as well as the initial characterization of the SnTox3 protein. SnTox3 is a 693 bp intron-free gene with little obvious homology to other known genes. The predicted immature ...Journal Article -
Predicting the Evolution of Sex on Complex Fitness Landscapes
(2009)PLoS Computational BiologyMost population genetic theories on the evolution of sex or recombination are based on fairly restrictive assumptions about the nature of the underlying fitness landscapes. Here we use computer simulations to study the evolution of sex on fitness landscapes with different degrees of complexity and epistasis. We evaluate predictors of the evolution of sex, which are derived from the conditions established in the population genetic literature ...Journal Article -
Genomic Diversity and Evolution of Mycobacterium ulcerans Revealed by Next-Generation Sequencing
(2009)PLoS PathogensMycobacterium ulcerans is the causative agent of Buruli ulcer, the third most common mycobacterial disease after tuberculosis and leprosy. It is an emerging infectious disease that afflicts mainly children and youths in West Africa. Little is known about the evolution and transmission mode of M. ulcerans, partially due to the lack of known genetic polymorphisms among isolates, limiting the application of genetic epidemiology. To systematically ...Journal Article -
Nutrition controls mitochondrial biogenesis in the drosophila adipose tissue through delg and cyclin D/Cdk4
(2009)PLoS ONEMitochondria are cellular organelles that perform critical metabolic functions: they generate energy from nutrients but also provide metabolites for de novo synthesis of fatty acids and several amino acids. Thus mitochondrial mass and activity must be coordinated with nutrient availability, yet this remains poorly understood. Here, we demonstrate that Drosophila larvae grown in low yeast food have strong defects in mitochondrial abundance ...Journal Article -
Investigating CTL Mediated Killing with a 3D Cellular Automaton
(2009)PLoS Computational BiologyCytotoxic T lymphocytes (CTLs) are important immune effectors against intra-cellular pathogens. These cells search for infected cells and kill them. Recently developed experimental methods in combination with mathematical models allow for the quantification of the efficacy of CTL killing in vivo and, hence, for the estimation of parameters that characterize the effect of CTL killing on the target cell populations. It is not known how these ...Journal Article -
Red Queen Dynamics with Non-Standard Fitness Interactions
(2009)PLoS Computational BiologyAntagonistic coevolution between hosts and parasites can involve rapid fluctuations of genotype frequencies that are known as Red Queen dynamics. Under such dynamics, recombination in the hosts may be advantageous because genetic shuffling can quickly produce disproportionately fit offspring (the Red Queen hypothesis). Previous models investigating these dynamics have assumed rather simple models of genetic interactions between hosts and ...Journal Article -
Genetic Variation in Healthy Oldest-Old
(2009)PLoS ONEIndividuals who live to 85 and beyond without developing major age-related diseases may achieve this, in part, by lacking disease susceptibility factors, or by possessing resistance factors that enhance their ability to avoid disease and prolong lifespan. Healthy aging is a complex phenotype likely to be affected by both genetic and environmental factors. We sequenced 24 candidate healthy aging genes in DNA samples from 47 healthy individuals ...Journal Article -
Illusionary Self-Motion Perception in Zebrafish
(2009)PLoS ONEZebrafish mutant belladonna (bel) carries a mutation in the lhx2 gene (encoding a Lim domain homeobox transcription factor) that results in a defect in retinotectal axon pathfinding, which can lead to uncrossed optic nerves failing to form an optic chiasm. Here, we report on a novel swimming behavior of the bel mutants, best described as looping. Together with two previously reported oculomotor instabilities that have been related to ...Journal Article -
Inclusive single-particle production in two-photon collisions at LEP II with the DELPHI detector
(2009)Physics Letters BA study of the inclusive charged hadron production in two-photon collisions is described. The data were collected with the DELPHI detector at LEP II. Results on the inclusive single-particle pT distribution and the differential charged hadrons d σ / d pT cross-section are presented and compared to the predictions of perturbative NLO QCD calculations and to published results.Journal Article -
Host Responses to Intestinal Microbial Antigens in Gluten-Sensitive Mice
(2009)PLoS ONEBackground and Aims Excessive uptake of commensal bacterial antigens through a permeable intestinal barrier may influence host responses to specific antigen in a genetically predisposed host. The aim of this study was to investigate whether intestinal barrier dysfunction induced by indomethacin treatment affects the host response to intestinal microbiota in gluten-sensitized HLA-DQ8/HCD4 mice. Methodology/Principal Findings HLA-DQ8/HCD4 ...Journal Article