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Giant optical nonlinearity interferences in quantum structures
(2019)Science AdvancesSecond-order optical nonlinearities can be greatly enhanced by orders of magnitude in resonantly excited nanostructures. These resonant nonlinearities continually attract attention, particularly in newly discovered materials. However, they are frequently not as heightened as currently predicted, limiting their exploitation in nanostructured nonlinear optics. Here, we present a clear-cut theoretical and experimental demonstration that the ...Journal Article -
Planning dam portfolios for low sediment trapping shows limits for sustainable hydropower in the Mekong
(2019)Science AdvancesThe transboundary Mekong Basin has been dubbed the “Battery of Southeast Asia” for its large hydropower potential. Development of hydropower dams in the six riparian countries proceeds without strategic analyses of dam impacts, e.g., reduced sediment delivery to the lower Mekong. This will impact some of the world’s largest freshwater fisheries and endangers the resilience of the delta, which supports 17 million livelihoods, against rising ...Journal Article -
Assessment of Cas12a‐mediated gene editing efficiency in plants
(2019)Plant Biotechnology JournalThe CRISPR/Cas12a editing system opens new possibilities for plant genome engineering. To obtain a comparative assessment of RNA‐guided endonuclease (RGEN) types in plants, we adapted the CRISPR/Cas12a system to the GoldenBraid (GB) modular cloning platform and compared the efficiency of Acidaminococcus (As) and Lachnospiraceae (Lb) Cas12a variants with the previously described GB‐assembled Streptococcus pyogenes Cas9 (SpCas9) constructs ...Journal Article -
Nocturnal Gamma-Hydroxybutyrate Reduces Cortisol-Awakening Response and Morning Kynurenine Pathway Metabolites in Healthy Volunteers
(2019)The International Journal of NeuropsychopharmacologyBackground Gamma-hydroxybutyrate (GHB; or sodium oxybate) is an endogenous GHB-/gamma-aminobutyric acid B receptor agonist. It is approved for application in narcolepsy and has been proposed for the potential treatment of Alzheimer’s disease, Parkinson’s disease, fibromyalgia, and depression, all of which involve neuro-immunological processes. Tryptophan catabolites (TRYCATs), the cortisol-awakening response (CAR), and brain-derived ...Journal Article -
Noise-footprint from Personal Land-Based Mobility
(2019)Journal of Industrial EcologyA large part of the world population is exposed to noise levels that are unhealthy. Yet noise is often neglected when impact assessment studies are conducted and when policy interventions are designed. In this study, we provide a way to calculate the noise footprint of citizens directly determined by their use of private and public transport on land. The study combines the results of the large transport simulation model MATSim applied to ...Journal Article -
Early Aβ reduction prevents progression of cerebral amyloid angiopathy
(2019)Annals of NeurologyObjective Clinical trials targeting β‐amyloid peptides (Aβ) for Alzheimer disease (AD) failed for arguable reasons that include selecting the wrong stages of AD pathophysiology or Aβ being the wrong target. Targeting Aβ to prevent cerebral amyloid angiopathy (CAA) has not been rigorously followed, although the causal role of Aβ for CAA and related hemorrhages is undisputed. CAA occurs with normal aging and to various degrees in AD, where ...Journal Article -
Welcome to Hotel Helvetia! Friedrich Wüthrich’s Illicit Mercenary Trade Network for the Dutch East Indies, 1858-1890
(2019)BMGN - Low Countries Historical ReviewBecause of limited human resources at home, the Dutch colonial army recruited up to forty percent of its soldiers outside of the Netherlands. This demand for mercenaries opened up a number of opportunities and challenges for non-Dutch European actors in a transnational military labour market. Among those who took advantage of these opportunities was the Swiss Friedrich Wüthrich. Born into a poor family, he first pursued a military career ...Journal Article -
Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations
(2019)Science AdvancesThe transition from land to water in whales and dolphins (cetaceans) was accompanied by remarkable adaptations. To reveal genomic changes that occurred during this transition, we screened for protein-coding genes that were inactivated in the ancestral cetacean lineage. We found 85 gene losses. Some of these were likely beneficial for cetaceans, for example, by reducing the risk of thrombus formation during diving (F12 and KLKB1), erroneous ...Journal Article -
Could revenue recycling make effective carbon taxation politically feasible?
(2019)Science AdvancesCarbon taxes are widely regarded as a potentially effective and economically efficient policy instrument for decarbonizing the global energy supply and thus limiting global warming. The main obstacle is political feasibility because of opposition from citizens and industry. Earmarking revenues from carbon taxation for spending that benefits citizens (i.e., revenue recycling) might help policy makers escape this political impasse. On the ...Journal Article -
Structural basis of sterol recognition by human hedgehog receptor PTCH1
(2019)Science AdvancesHedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4-Å cryo-EM structure of the human PTCH1 bound to ShhNC24II, a modified hedgehog ligand mimicking its palmitoylated form. The membrane-embedded part of ...Journal Article